A waiting time problem arising from the study of multi-stage carcinogenesis

DOI10.1214/08-AAP559zbMATH Open1219.92038arXiv0707.2057MaRDI QIDQ1024901FDOQ1024901

Authors: Rick Durrett, Deena R. Schmidt, Jason Schweinsberg 

Publication date: 17 June 2009

Published in: The Annals of Applied Probability (Search for Journal in Brave)

Abstract: We consider the population genetics problem: how long does it take before some member of the population has $m$ specified mutations? The case $m=2$ is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger $m$ are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

Full work available at URL: https://arxiv.org/abs/0707.2057

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zbMATH Keywords

Wright-Fisher diffusionMoran modelwaiting times

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of branching processes (60J85) Continuous-time Markov processes on general state spaces (60J25)

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Cited In (30)

• Using statistical methods to model the fine-tuning of molecular machines and systems
• Exponentiality of first passage times of continuous time Markov chains
• Evolutionary games with affine fitness functions: applications to cancer
• A bivariate limiting distribution of tumor latency time
• The coalescence of intrahost HIV lineages under symmetric CTL attack
• On \(\Lambda\)-Fleming-Viot processes with general frequency-dependent selection
• Multifocality and recurrence risk: a quantitative model of field cancerization
• Waiting for \(m\) mutations
• The calculation of mean first arrival time for double mutants, crossing the fitness valley
• Waiting time models of cancer progression
• Cancer initiation with epistatic interactions between driver and passenger mutations
• Evolutionary dynamics of tumor progression with random fitness values
• OPTIMAL CONTROL OF GENETIC DIVERSITY IN THE MORAN MODEL WITH POPULATION GROWTH
• On the waiting time until coordinated mutations get fixed in regulatory sequences
• Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
• To what extent does genealogical ancestry imply genetic ancestry?
• Spatial Moran models I. stochastic tunneling in the neutral case
• The waiting time for a second mutation: an alternative to the Moran model
• A spatial mutation model with increasing mutation rates
• Evolution of resistance and progression to disease during clonal expansion of cancer
• Multitype branching processes in random environment
• Accumulation of oncogenic mutations during progression from healthy tissue to cancer
• Population genetics of tumor suppressor genes
• The rate of multi-step evolution in Moran and Wright-Fisher populations
• Traveling waves of selective sweeps
• Queue hurdle Coxian phase-type model for two-stage process of population-based cancer screening
• Moran process version of the tug-of-war model: behavior revealed by mathematical analysis and simulation studies
• Multi-type age-dependent branching processes as models of metastasis evolution
• Mutation timing in a spatial model of evolution
• A hierarchical probability model of colon cancer

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