A waiting time problem arising from the study of multi-stage carcinogenesis
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Abstract: We consider the population genetics problem: how long does it take before some member of the population has specified mutations? The case is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.
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Cited in
(30)- A hierarchical probability model of colon cancer
- Using statistical methods to model the fine-tuning of molecular machines and systems
- Exponentiality of first passage times of continuous time Markov chains
- Evolutionary games with affine fitness functions: applications to cancer
- A bivariate limiting distribution of tumor latency time
- The coalescence of intrahost HIV lineages under symmetric CTL attack
- On \(\Lambda\)-Fleming-Viot processes with general frequency-dependent selection
- Multifocality and recurrence risk: a quantitative model of field cancerization
- Waiting for \(m\) mutations
- The calculation of mean first arrival time for double mutants, crossing the fitness valley
- Waiting time models of cancer progression
- Evolutionary dynamics of tumor progression with random fitness values
- Cancer initiation with epistatic interactions between driver and passenger mutations
- OPTIMAL CONTROL OF GENETIC DIVERSITY IN THE MORAN MODEL WITH POPULATION GROWTH
- On the waiting time until coordinated mutations get fixed in regulatory sequences
- Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
- To what extent does genealogical ancestry imply genetic ancestry?
- Spatial Moran models I. stochastic tunneling in the neutral case
- The waiting time for a second mutation: an alternative to the Moran model
- A spatial mutation model with increasing mutation rates
- Evolution of resistance and progression to disease during clonal expansion of cancer
- Multitype branching processes in random environment
- Accumulation of oncogenic mutations during progression from healthy tissue to cancer
- Population genetics of tumor suppressor genes
- Traveling waves of selective sweeps
- The rate of multi-step evolution in Moran and Wright-Fisher populations
- Queue hurdle Coxian phase-type model for two-stage process of population-based cancer screening
- Moran process version of the tug-of-war model: behavior revealed by mathematical analysis and simulation studies
- Multi-type age-dependent branching processes as models of metastasis evolution
- Mutation timing in a spatial model of evolution
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