Using statistical methods to model the fine-tuning of molecular machines and systems

DOI10.1016/j.jtbi.2020.110352zbMath1455.92065OpenAlexW3033459730WikidataQ96160390 ScholiaQ96160390MaRDI QIDQ827877

Steinar Thorvaldsen, Ola G. Hössjer

Publication date: 13 January 2021

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2020.110352

zbMATH Keywords

complexitymodel selectionspecificityBayesianfine-tuningintelligent designwaiting time problem

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Related Items (2)

Sometimes size does not matter ⋮ Is cosmological tuning fine or coarse?

Uses Software

• DOS

Cites Work

• A waiting time problem arising from the study of multi-stage carcinogenesis
• Statistical decision theory and Bayesian analysis. 2nd ed
• The fundamental theorem of natural selection with mutations
• Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
• Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
• Waiting for regulatory sequences to appear
• Biological function and the genetic code are interdependent
• Problems with the argument from fine tuning
• Model of effectively neutral mutations in which selective constraint is incorporated
• Probability Models for DNA Sequence Evolution
• Frontiers of Statistical Decision Making and Bayesian Analysis
• The Design Inference
• Design of observational studies
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