Model of effectively neutral mutations in which selective constraint is incorporated

DOI10.1073/PNAS.76.7.3440zbMATH Open0416.92007OpenAlexW2055346334WikidataQ37337060 ScholiaQ37337060MaRDI QIDQ3206702FDOQ3206702

Authors: Motoo Kimura 

Publication date: 1979

Published in: Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1073/pnas.76.7.3440

zbMATH Keywords

population geneticsmolecular evolutionprotein polymorphismselective constraintmodel of infinite sitesneutral mutation theory

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) General biology and biomathematics (92B05)

Cited In (11)

• Using statistical methods to model the fine-tuning of molecular machines and systems
• The role of population size in molecular evolution
• The fundamental theorem of natural selection with mutations
• A simple stochastic gene substitution model
• On the waiting time until coordinated mutations get fixed in regulatory sequences
• Inference for one-step beneficial mutations using next generation sequencing
• Finding important sites in protein sequences
• Quantifying the impact of changes in effective population size and expression level on the rate of coding sequence evolution
• Formal properties of the probability of fixation: identities, inequalities and approximations
• A model of electrophoretic variation: Finite populations and finite numbers of mutable sites
• Back to the fundamentals: a reply to Basener and Sanford 2018

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