Model of effectively neutral mutations in which selective constraint is incorporated

DOI10.1073/PNAS.76.7.3440MaRDI QIDQ3206702zbMATH OpenOpenAlexWikidataFDO

Authors Motoo Kimura

Publication date 1979

Published in Proceedings of the National Academy of Sciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1073/pnas.76.7.3440

zbMATH Keywords

model of infinite sitesmolecular evolutionneutral mutation theorypopulation geneticsprotein polymorphismselective constraint

Mathematics Subject Classification ID

General biology and biomathematics (92B05) Genetics and epigenetics (92D10)

Cited in

(11)

• A model of electrophoretic variation: Finite populations and finite numbers of mutable sites
• The role of population size in molecular evolution
• The fundamental theorem of natural selection with mutations
• A simple stochastic gene substitution model
• On the waiting time until coordinated mutations get fixed in regulatory sequences
• Quantifying the impact of changes in effective population size and expression level on the rate of coding sequence evolution
• Inference for one-step beneficial mutations using next generation sequencing
• Finding important sites in protein sequences
• Formal properties of the probability of fixation: identities, inequalities and approximations
• Back to the fundamentals: a reply to Basener and Sanford 2018
• Using statistical methods to model the fine-tuning of molecular machines and systems

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