Evolutionary games with affine fitness functions: applications to cancer

DOI10.1007/S13235-011-0029-0zbMATH Open1252.91031arXiv1101.4861OpenAlexW3100792164MaRDI QIDQ692096FDOQ692096

Authors: Moritz Gerstung, Hani Nakhoul, Niko Beerenwinkel 

Publication date: 4 December 2012

Published in: Dynamic Games and Applications (Search for Journal in Brave)

Abstract: We analyze the dynamics of evolutionary games in which fitness is defined as an affine function of the expected payoff and a constant contribution. The resulting inhomogeneous replicator equation has an homogeneous equivalent with modified payoffs. The affine terms also influence the stochastic dynamics of a two-strategy Moran model of a finite population. We then apply the affine fitness function in a model for tumor-normal cell interactions to determine which are the most successful tumor strategies. In order to analyze the dynamics of concurrent strategies within a tumor population, we extend the model to a three-strategy game involving distinct tumor cell types as well as normal cells. In this model, interaction with normal cells, in combination with an increased constant fitness, is the most effective way of establishing a population of tumor cells in normal tissue.

Full work available at URL: https://arxiv.org/abs/1101.4861

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zbMATH Keywords

cancerprisoner's dilemmareplicator equationstromaevolutionary game theoryMoran process

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of game theory (91A80) Evolutionary games (91A22)

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Cited In (8)

• A simple evolutionary game arising from the study of the role of IGF-II in pancreatic cancer
• Estimating the probability of coexistence in cross-feeding communities
• How to analyze models of nonlinear public goods
• Game theory of tumor-stroma interactions in multiple myeloma: effect of nonlinear benefits
• The contribution of evolutionary game theory to understanding and treating cancer
• Inactivation of tumor suppressor genes and cancer therapy: an evolutionary game theory approach
• Games and the treatment convexity of cancer
• Evolutionary game theory in an agent-based brain tumor model: exploring the `genotype-phenotype' link

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