Evolutionary games with affine fitness functions: applications to cancer

DOI10.1007/S13235-011-0029-0MaRDI QIDQ692096zbMATH OpenOpenAlexFDO

Authors Moritz Gerstung, Hani Nakhoul, Niko Beerenwinkel

Publication date 4 December 2012

Published in Dynamic Games and Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1101.4861

zbMATH Keywords

cancerprisoner's dilemmareplicator equationstromaevolutionary game theoryMoran process

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of game theory (91A80) Evolutionary games (91A22)

Abstract: We analyze the dynamics of evolutionary games in which fitness is defined as an affine function of the expected payoff and a constant contribution. The resulting inhomogeneous replicator equation has an homogeneous equivalent with modified payoffs. The affine terms also influence the stochastic dynamics of a two-strategy Moran model of a finite population. We then apply the affine fitness function in a model for tumor-normal cell interactions to determine which are the most successful tumor strategies. In order to analyze the dynamics of concurrent strategies within a tumor population, we extend the model to a three-strategy game involving distinct tumor cell types as well as normal cells. In this model, interaction with normal cells, in combination with an increased constant fitness, is the most effective way of establishing a population of tumor cells in normal tissue.

Recommendations

• Application of evolutionary games to modeling carcinogenesis
• CARCINOGENESIS AS AN EVOLUTIONARY GAME
• MODELING CANCER AS AN EVOLUTIONARY GAME
• A simple evolutionary model for cancer cell population and its implications on cancer therapy
• Spatial Evolutionary Games of Interaction among Generic Cancer Cells

Cites work

• scientific article; zbMATH DE number 3835792 (Why is no real title available?)
• scientific article; zbMATH DE number 3493681 (Why is no real title available?)
• scientific article; zbMATH DE number 3194920 (Why is no real title available?)
• A waiting time problem arising from the study of multi-stage carcinogenesis
• Analytical results for individual and group selection of any intensity
• Dynamics of small autocatalytic reaction networks. I: Bifurcations, permanence and exclusion
• Evolutionarily stable strategies and game dynamics
• Evolutionary Games and Population Dynamics
• Evolutionary dynamics. Exploring the equations of life.
• Evolutionary game dynamics
• Evolutionary game dynamics in finite populations
• Evolutionary game dynamics in finite populations with strong selection and weak mutation
• Evolutionary game dynamics with non-uniform interaction rates
• Fixation of strategies for an evolutionary game in finite populations
• Lotka-Volterra equation and replicator dynamics: A two-dimensional classification
• Spatial Evolutionary Games of Interaction among Generic Cancer Cells
• The evolution of cooperation
• The probability of fixation of a single mutant in an exchangeable selection model
• Waiting time models of cancer progression

Cited in

(8)

• A simple evolutionary game arising from the study of the role of IGF-II in pancreatic cancer
• Estimating the probability of coexistence in cross-feeding communities
• How to analyze models of nonlinear public goods
• Game theory of tumor-stroma interactions in multiple myeloma: effect of nonlinear benefits
• The contribution of evolutionary game theory to understanding and treating cancer
• Inactivation of tumor suppressor genes and cancer therapy: an evolutionary game theory approach
• Games and the treatment convexity of cancer
• Evolutionary game theory in an agent-based brain tumor model: exploring the `genotype-phenotype' link

This page was built for publication: Evolutionary games with affine fitness functions: applications to cancer

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q692096)