The waiting time for a second mutation: an alternative to the Moran model

DOI10.1016/J.PHYSA.2014.01.031MaRDI QIDQ1782683zbMATH OpenOpenAlexFDO

Authors Rinaldo Schinazi

Publication date 20 September 2018

Published in Physica A (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1306.6919

zbMATH Keywords

Moranmutationstochastic modelwaiting time

Mathematics Subject Classification ID

Cell biology (92C37) Medical applications (general) (92C50)

Abstract: The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.

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Cites work

• A waiting time problem arising from the study of multi-stage carcinogenesis
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• scientific article; zbMATH DE number 2150813 (Why is no real title available?)
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Cited in

(6)

• Waiting for \(m\) mutations
• Branching processes in continuous time as models of mutations: computational approaches and algorithms
• Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
• Waiting time models of cancer progression
• A hierarchical probability model of colon cancer
• Waiting times to appearance and dominance of advantageous mutants: Estimation based on the likelihood

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