Mutation timing in a spatial model of evolution

DOI10.1016/J.SPA.2020.05.015MaRDI QIDQ2196552zbMATH OpenOpenAlexFDO

Authors Jasmine Foo, Kevin Leder, Jason Schweinsberg

Publication date 3 September 2020

Published in Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2001.01175

zbMATH Keywords

cancermutationsspatial population model

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Interacting random processes; statistical mechanics type models; percolation theory (60K35) Pathology, pathophysiology (92C32)

Abstract: Motivated by models of cancer formation in which cells need to acquire $k$ mutations to become cancerous, we consider a spatial population model in which the population is represented by the $d$-dimensional torus of side length $L$. Initially, no sites have mutations, but sites with $i-1$ mutations acquire an $i$th mutation at rate $m{u}_i$ per unit area. Mutations spread to neighboring sites at rate $alpha$, so that $t$ time units after a mutation, the region of individuals that have acquired the mutation will be a ball of radius $alphat$. We calculate, for some ranges of the parameter values, the asymptotic distribution of the time required for some individual to acquire $k$ mutations. Our results, which build on previous work of Durrett, Foo, and Leder, are essentially complete when $k=2$ and when $m{u}_i=mu$ for all $i$.

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Cited in

(13)

• Time inhomogeneous mutation models with birth date dependence
• Dynamics of advantageous mutant spread in spatial death-birth and birth-death Moran models
• Evolution of resistance and progression to disease during clonal expansion of cancer
• On spatial mutation-selection models
• Spread of premalignant mutant clones and cancer initiation in multilayered tissue
• Modeling the impact of periodic bottlenecks, unidirectional mutation, and observational error in experimental evolution
• Waiting for \(m\) mutations
• A hierarchical probability model of colon cancer
• Traveling waves of selective sweeps
• Spatial stochastic models for cancer initiation and progression
• Spatial Moran models. II: Cancer initiation in spatially structured tissue
• The waiting time for a second mutation: an alternative to the Moran model
• A spatial mutation model with increasing mutation rates

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