A hierarchical probability model of colon cancer

DOI10.1239/AAP/1354716589MaRDI QIDQ4906507zbMATH OpenOpenAlexFDO

Authors

Publication date 28 February 2013

Published in Advances in Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1005.3451, https://projecteuclid.org/euclid.aap/1354716589

zbMATH Keywords

cancermutationPoisson processpopulation model

Mathematics Subject Classification ID

Point processes (e.g., Poisson, Cox, Hawkes processes) (60G55) Markov processes (60J99) Medical applications (general) (92C50)

Abstract: We consider a model of fixed size $N=2^l$ in which there are $l$ generations of daughter cells and a stem cell. In each generation $i$ there are $2^{i-1}$ daughter cells. At each integral time unit the cells split so that the stem cell splits into a stem cell and generation 1 daughter cell and the generation $i$ daughter cells become two cells of generation $i+1$. The last generation is removed from the population. The stem cell gets first and second mutations at rates $u_1$ and $u_2$ and the daughter cells get first and second mutations at rates $v_1$ and $v_2$. We find the distribution for the time it takes to get two mutations as $N$ goes to infinity and the mutation rates go to 0. We also find the distribution for the location of the mutations. Several outcomes are possible depending on how fast the rates go to 0. The model considered has been proposed by Komarova (2007) as a model for colon cancer.

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Cites work

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Cited in

(3)

• The waiting time for a second mutation: an alternative to the Moran model
• Predicting the Whole Distribution with Methods for Depth Data Analysis Demonstrated on a Colorectal Cancer Treatment Study
• A spatial mutation model with increasing mutation rates

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