A spatial mutation model with increasing mutation rates

Abstract: We consider a spatial model of cancer in which cells are points on the

d

-dimensional torus

m a t h c a l T = [0, L]^{d}

, and each cell with

k - 1

mutations acquires a

k

th mutation at rate

m u_{k}

. We will assume that the mutation rates

m u_{k}

are increasing, and we find the asymptotic waiting time for the first cell to acquire

k

mutations as the torus volume tends to infinity. This paper generalizes results on waiting for

k g e q 3

mutations by Foo, Leder, and Schweinsberg, who considered the case in which all of the mutation rates

m u_{k}

were the same. In addition, we find the limiting distribution of the spatial distances between mutations for certain values of the mutation rates.

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