Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models

DOI10.1007/S10955-006-9238-0MaRDI QIDQ2641406zbMATH OpenOpenAlexFDO

Authors Natalia L. Komarova

Publication date 20 August 2007

Published in Journal of Statistical Physics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s10955-006-9238-0

zbMATH Keywords

Moran processstem cellsstochastic tunnelingnearest neighbor interactionsoncogenestumor suppressor genesfinite branching processhomeostatic control

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of branching processes (60J85) Population dynamics (general) (92D25) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80)

Recommendations

• STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER
• Spatial Moran models. II: Cancer initiation in spatially structured tissue
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• Somatic selection for and against cancer
• Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

Cites work

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• scientific article; zbMATH DE number 1321103 (Why is no real title available?)
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• A stochastic carcinogenesis model incorporating genomic instability fitted to colon cancer data
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• Epithelial tissue architecture protects against cancer
• MATHEMATICAL METHODS AND TOOLS OF KINETIC THEORY TOWARDS MODELLING COMPLEX BIOLOGICAL SYSTEMS
• MATHEMATICAL MODELLING OF CANCER CELL INVASION OF TISSUE: THE ROLE OF THE UROKINASE PLASMINOGEN ACTIVATION SYSTEM
• MATHEMATICAL TOPICS ON THE MODELLING COMPLEX MULTICELLULAR SYSTEMS AND TUMOR IMMUNE CELLS COMPETITION
• Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
• Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
• Spatial stochastic models for cancer initiation and progression
• Stochastic modeling of carcinogenesis: Some new insights
• Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions

Cited in

(13)

• A hierarchical probability model of colon cancer
• Spatial stochastic models for cancer initiation and progression
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• Gain and loss of function mutations in biological chemical reaction networks: a mathematical model with application to colorectal cancer cells
• STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER
• Structure-functional prediction and analysis of cancer mutation effects in protein kinases
• Spatial invasion dynamics on random and unstructured meshes: implications for heterogeneous tumor populations
• Spatial Moran models I. stochastic tunneling in the neutral case
• A general multi-scale description of metastable adaptive motion across fitness valleys
• Spread of premalignant mutant clones and cancer initiation in multilayered tissue
• Somatic selection for and against cancer
• Epithelial tissue architecture protects against cancer
• A stochastic model of cancer initiation including a bystander effect

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• pyuvdata

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