Two-mutation model for carcinogenesis: Joint analysis of premalignant and malignant lesions

DOI10.1016/0025-5564(91)90032-EMaRDI QIDQ2277188zbMATH OpenOpenAlexWikidataFDO

Authors Anup Dewanji, Suresh Moolgavkar, E. G. Luebeck

Publication date 1991

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(91)90032-e

zbMATH Keywords

altered hepatic foci in rodentscarcinogenesisgeneralization of the recessive oncogenesis hypothesisinactivation of homologous tumor suppressor genesmalignant transformationpremalignant lesions

Mathematics Subject Classification ID

Applications of branching processes (60J85) Medical applications (general) (92C50)

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Cites work

• A stochastic Gompertz birth-death process
• scientific article; zbMATH DE number 3599249 (Why is no real title available?)
• Partial differential equations
• Some Stochastic Models for Small Epidemics in Large Populations
• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors

Cited in

(22)

• A model of multiple tumorigenesis allowing for cell death: Quantitative insight into biological effects of urethane
• Two stage model for carcinogenesis: Number and size distributions of premalignant clones in longitudinal studies
• Quantitative analysis of two-dimensional observations of premalignant clones in the presence or absence of malignant tumors
• Simulating the process of malignant transformation
• A carcinogenesis model describing mutational events at the DNA adduct level
• A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
• Stochastic modeling of carcinogenesis: Some new insights
• A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
• Stochastic simulation of a multistage model of carcinogenesis
• A biologically based model for the analysis of premalignant foci of arbitrary shape
• Incorporating observability thresholds of tumors into the two-stage carcinogenesis model
• An application of a two-level non-Gaussian state-space model in the analysis of longitudinal papilloma count data
• Spatial stochastic models for cancer initiation and progression
• Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models
• scientific article; zbMATH DE number 3924570 (Why is no real title available?)
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll
• The analysis of incomplete data using stochastic covariates
• Stability Analysis and Comparison of the Models for Carcinogenesis Mutations in the Case of Two Stages of Mutations
• STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER
• A mixed model of carcinogenesis with applications to retinoblastoma
• A stereological method for the analysis of celluar lesions in tissue sections using three-dimensional cellular automata
• Spread of premalignant mutant clones and cancer initiation in multilayered tissue

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