Stochastic Modelling of Multiple Random Genetic Mutations Under the Cancer Stem Cell Hypothesis

DOI10.1080/08898480.2012.725379MaRDI QIDQ4628522zbMATH OpenOpenAlexFDO

Authors Cristian Tomasetti

Publication date 14 March 2019

Published in Mathematical Population Studies (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/08898480.2012.725379

zbMATH Keywords

tumor growthbranching processesstem cellstumor heterogeneitygenetic mutations

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Applications of branching processes (60J85) Population dynamics (general) (92D25) Developmental biology, pattern formation (92C15)

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Cites work

• scientific article; zbMATH DE number 3410334 (Why is no real title available?)
• A stochastic model for the origin and treatment of tumors containing drug-resistant cells
• Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations
• Evolution of resistance and progression to disease during clonal expansion of cancer
• Population-size-dependent, age-structured branching processes linger around
• Viability of Small Populations Experiencing Recurring Catastrophes
• Waiting time models of cancer progression

Cited in

(14)

• On the probability of random genetic mutations for various types of tumor growth
• Probabilistic methods in cancer biology
• Probability distribution of the number of initiated cells of carcinogenesis under prevention
• Evolutionary dynamics of tumor progression with random fitness values
• STOCHASTIC MODELING OF LOSS- AND GAIN-OF-FUNCTION MUTATIONS IN CANCER
• Somatic mosaicism and cancer: inference based on a conditional Luria-Delbrück distribution
• A stochastic model of chromosome segregation errors with reference to cancer cells
• Erratum to ``A stochastic carcinogenesis model incorporating multiple types of genomic instability fitted to colon cancer data
• A stochastic model of mutant growth due to mutation in tumors, based on stem cell considerations
• A sticky multinomial mixture model of strand-coordinated mutational processes in cancer
• Loss- and gain-of-function mutations in cancer: mass-action, spatial and hierarchical models
• A stochastic model of mutant growth
• A Statistical Test of the Hypothesis that Polyclonal Intestinal Tumors Arise by Random Collision of Initiated Clones
• Spatial measures of genetic heterogeneity during carcinogenesis

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