Examining the rare disease assumption used to justify HWE testing with control samples

DOI10.3934/MBE.2020004zbMATH Open1470.92149OpenAlexW2976067569WikidataQ91298243 ScholiaQ91298243MaRDI QIDQ2045652FDOQ2045652

Authors: Virginia L. Ma, Shili Lin 

Publication date: 13 August 2021

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.3934/mbe.2020004

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zbMATH Keywords

case-control studygenome-wide association studiesHardy-Weinberg equilibrium1000 genomes projectrare disease assumption

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Genetics and epigenetics (92D10)

Cites Work

• Robust partial likelihood approach for detecting imprinting and maternal effects using case-control families
• The Foreign Trade Accelerator and the International Transmission of Growth

Cited In (1)

• The number of candidate variants in exome sequencing for Mendelian disease under no genetic heterogeneity

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