Effect of diverse recoding of granule cells on optokinetic response in a cerebellar ring network with synaptic plasticity

DOI10.1101/2020.03.25.007245MaRDI QIDQ2055069zbMATH OpenOpenAlexWikidataFDO

Authors Sang-Yoon Kim, Woochang Lim

Publication date 3 December 2021

Published in Neural Networks (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2003.11325

zbMATH Keywords

cerebellar ring networkdiverse recordingeffective long-term depressioneffective motor learningoptokinetic response

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: We consider a cerebellar ring network for the optokinetic response (OKR), and investigate the effect of diverse recoding of granule (GR) cells on OKR by varying the connection probability $p_c$ from Golgi to GR cells. For an optimal value of $p_c^{\ast }(=0.06)$, individual GR cells exhibit diverse spiking patterns which are in-phase, anti-phase, or complex out-of-phase with respect to their population-averaged firing activity. Then, these diversely-recoded signals via parallel fibers (PFs) from GR cells are effectively depressed by the error-teaching signals via climbing fibers from the inferior olive which are also in-phase ones. Synaptic weights at in-phase PF-Purkinje cell (PC) synapses of active GR cells are strongly depressed via strong long-term depression (LTD), while those at anti-phase and complex out-of-phase PF-PC synapses are weakly depressed through weak LTD. This kind of "effective" depression (i.e., strong/weak LTD) at the PF-PC synapses causes a big modulation in firings of PCs, which then exert effective inhibitory coordination on the vestibular nucleus (VN) neuron (which evokes OKR). For the firing of the VN neuron, the learning gain degree ${calL}_g$, corresponding to the modulation gain ratio, increases with increasing the learning cycle, and it saturates at about the 300th cycle. By varying $p_c$ from $p_c^{\ast }$, we find that a plot of saturated learning gain degree ${calL}_g^{\ast }$ versus $p_c$ forms a bell-shaped curve with a peak at $p_c^{\ast }$ (where the diversity degree in spiking patterns of GR cells is also maximum). Consequently, the more diverse in recoding of GR cells, the more effective in motor learning for the OKR adaptation.

Review text

This paper focuses on the cerebellar mechanism for gain and timing control for eye movements, actually more on the gain control for the optokinetic response (OKR). The authors are using the neural network technology and are inspired by earlier research in this domain. One introduces a cerebellar ring network with synaptic plasticity for the optokinetic response adaptation. The ring is composed of a granular layer, the Purkinje-molecular layer and the VN-IO part. The second section of the article is devoted to a detailed presentation of the architecture of the ring network. One shows the used leaky integrate-and-fire (LIF) neuron model, the equations governing the dynamics in the model together with a description of the synaptic currents and synaptic plasticity. The effect of different ways of recording the granule (GR) cells on motor learning for the OKR adaptation by means of varying the connection probability \(p_c\) from the Golgi (GO) to GR cells is largely investigated in the third section. One studies different cases as the firing activity in the population of GR cells, the dynamical classification of spiking patterns of GR clusters, the effect of diverse recording in GR clusters on synaptic plasticity at PF-PC synapses or the effect of PF-PC synaptic plasticity on the learning process in the PC-VN-IO system. Comments and a large discussion on present results, and the connection to earlier works on same subject and future trends are contained in the last section of the paper.

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Cites work

• A mathematical model of the cerebellar-olivary system. I: Self-regulating equilibrium of climbing fiber activity
• Adaptive filter model of the cerebellum
• Collective dynamics of `small-world' networks
• Dynamics of sparsely connected networks of excitatory and inhibitory spiking neurons.
• Exploring complex networks
• How Noise Affects the Synchronization Properties of Recurrent Networks of Inhibitory Neurons
• scientific article; zbMATH DE number 167591 (Why is no real title available?)
• Kernel bandwidth optimization in spike rate estimation
• Real-Time Computing Without Stable States: A New Framework for Neural Computation Based on Perturbations
• Spiking Neuron Models
• The cerebellum as a liquid state machine

Cited in

(3)

• A mathematical model of the cerebellar-olivary system. II: Motor adaptation through systematic disruption of climbing fiber equilibrium
• Analysis of output of all Purkinje cells controlled by one climbing fiber cell
• Electrical coupling regulated by GABAergic nucleo-olivary afferent fibres facilitates cerebellar sensory-motor adaptation

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