Effect of diverse recoding of granule cells on optokinetic response in a cerebellar ring network with synaptic plasticity

DOI10.1101/2020.03.25.007245MaRDI QIDQ2055069zbMATH OpenOpenAlexWikidataFDO

Authors Sang-Yoon Kim, Woochang Lim

Publication date 3 December 2021

Published in Neural Networks (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2003.11325

zbMATH Keywords

cerebellar ring networkdiverse recordingeffective long-term depressioneffective motor learningoptokinetic response

Mathematics Subject Classification ID

Neural networks for/in biological studies, artificial life and related topics (92B20)

Abstract: We consider a cerebellar ring network for the optokinetic response (OKR), and investigate the effect of diverse recoding of granule (GR) cells on OKR by varying the connection probability $p_c$ from Golgi to GR cells. For an optimal value of $p_c^{\ast }(=0.06)$, individual GR cells exhibit diverse spiking patterns which are in-phase, anti-phase, or complex out-of-phase with respect to their population-averaged firing activity. Then, these diversely-recoded signals via parallel fibers (PFs) from GR cells are effectively depressed by the error-teaching signals via climbing fibers from the inferior olive which are also in-phase ones. Synaptic weights at in-phase PF-Purkinje cell (PC) synapses of active GR cells are strongly depressed via strong long-term depression (LTD), while those at anti-phase and complex out-of-phase PF-PC synapses are weakly depressed through weak LTD. This kind of "effective" depression (i.e., strong/weak LTD) at the PF-PC synapses causes a big modulation in firings of PCs, which then exert effective inhibitory coordination on the vestibular nucleus (VN) neuron (which evokes OKR). For the firing of the VN neuron, the learning gain degree ${calL}_g$, corresponding to the modulation gain ratio, increases with increasing the learning cycle, and it saturates at about the 300th cycle. By varying $p_c$ from $p_c^{\ast }$, we find that a plot of saturated learning gain degree ${calL}_g^{\ast }$ versus $p_c$ forms a bell-shaped curve with a peak at $p_c^{\ast }$ (where the diversity degree in spiking patterns of GR cells is also maximum). Consequently, the more diverse in recoding of GR cells, the more effective in motor learning for the OKR adaptation.

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Cites work

• scientific article; zbMATH DE number 167591 (Why is no real title available?)
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Cited in

(2)

• Analysis of output of all Purkinje cells controlled by one climbing fiber cell
• Electrical coupling regulated by GABAergic nucleo-olivary afferent fibres facilitates cerebellar sensory-motor adaptation

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