Monostability and bistability of biological switches

DOI10.1007/S00285-021-01687-YMaRDI QIDQ2059530zbMATH OpenOpenAlexWikidataFDO

Authors Jules Guilberteau, Camille Pouchol, Nastassia Pouradier Duteil

Publication date 14 December 2021

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2104.04227

zbMATH Keywords

asymptotic multistabilitybasins of attractioncooperative and competitive ODEdynamical systemsfixed pointstoggle switch

Mathematics Subject Classification ID

Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Qualitative investigation and simulation of ordinary differential equation models (34C60) Stability of solutions to ordinary differential equations (34D20) General biology and biomathematics (92B05)

Abstract: Cell-fate transition can be modeled by ordinary differential equations (ODEs) which describe the behavior of several molecules in interaction, and for which each stable equilibrium corresponds to a possible phenotype (or 'biological trait'). In this paper, we focus on simple ODE systems modeling two molecules which each negatively (or positively) regulate the other. It is well-known that such models may lead to monostability or multistability, depending on the selected parameters. However, extensive numerical simulations have led systems biologists to conjecture that in the vast majority of cases, there cannot be more than two stable points. Our main result is a proof of this conjecture. More specifically, we provide a criterion ensuring at most bistability, which is indeed satisfied by most commonly used functions. This includes Hill functions, but also a wide family of convex and sigmoid functions. We also determine which parameters lead to monostability, and which lead to bistability, by developing a more general framework encompassing all our results.

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Cites work

• scientific article; zbMATH DE number 50840 (Why is no real title available?)
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• Why are cellular switches Boolean? General conditions for multistable genetic circuits

Cited in

(12)

• Why are cellular switches Boolean? General conditions for multistable genetic circuits
• Transition between monostability and bistability of a genetic toggle switch in Escherichia coli
• Two classes of ODE models with switch-like behavior
• Bistable stochastic biochemical networks: highly specific systems with few chemicals
• Stability analysis of a signaling circuit with dual species of gtpase switches
• scientific article; zbMATH DE number 6907753 (Why is no real title available?)
• Bistable behaviour of some models in mathematical biology
• Analysis of a Model Biological Switch
• Bistable switching asymptotics for the self regulating gene
• Boolean models of bistable biological systems
• Bistability and oscillatory behaviours of cyclic feedback loops
• Bifurcation analysis for gene regulatory networks embedding a toggle-switch model: application to X chromosome inactivation

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