Two classes of ODE models with switch-like behavior

DOI10.1016/J.PHYSD.2013.08.008MaRDI QIDQ2448665zbMATH OpenOpenAlexWikidataFDO

Authors Winfried Just, Mason Korb, Ben Elbert, Todd R. Young

Publication date 5 May 2014

Published in Physica D (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1302.5396, http://europepmc.org/articles/pmc3825125

zbMATH Keywords

Boolean systemBoolean approximation of flowcomparing dynamical systems modelsconsistency between models

Mathematics Subject Classification ID

Control/observation systems governed by ordinary differential equations (93C15) Control/observation systems governed by functional relations other than differential equations (such as hybrid and switching systems) (93C30)

Abstract: In cases where the same real-world system can be modeled both by an ODE system $$ and a Boolean system $$ it is of interest to identify conditions under which the two systems will be consistent, that is, will make qualitatively equivalent predictions. In this note we introduce two broad classes of relatively simple models that provide a convenient framework for studying such questions. In contrast to the widely known class of Glass networks, the right-hand sides of our ODEs are Lipschitz-continuous. We prove that under suitable assumptions about $$ consistency between $$ and $$ will be implied by sufficient separation of time scales in one class of our models while it may fail in the other class. These results appear to point to more general structure properties that favor consistency between ODE and Boolean models.

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Cites work

• Analysis of continuous-time switching networks
• Boolean dynamics with random couplings
• Comparing different ODE modelling approaches for gene regulatory networks
• Dynamics of actively regulated gene networks
• Mathematical concepts and methods in modern biology. Using modern discrete models
• Reducing neuronal networks to discrete dynamics

Cited in

(3)

• Relations between the conditions of admitting cycles in Boolean and ODE network systems
• Comparison of combinatorial signatures of global network dynamics generated by two classes of ODE models
• Approximating network dynamics: some open problems

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