A mathematical description of bacterial chemotaxis in response to two stimuli

DOI10.1007/S11538-021-00965-6zbMATH Open1476.92011arXiv2006.00688OpenAlexW3215141087WikidataQ113900104 ScholiaQ113900104MaRDI QIDQ2060044FDOQ2060044

Authors: Jeungeun Park, Zahra Aminzare 

Publication date: 13 December 2021

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: Bacteria are often exposed to multiple stimuli in complex environments, and their efficient chemotactic decisions are critical to survive and grow in their native environments. Bacterial responses to the environmental stimuli depend on the ratio of their corresponding chemoreceptors. By incorporating the signaling machinery of individual cells, we analyze the collective motion of a population of Escherichia coli bacteria in response to two stimuli, mainly serine and methyl-aspartate (MeAsp), in a one-dimensional and a two-dimensional environment, which is inspired by experimental results in Y. Kalinin et al., J. Bacteriol. 192(7):1796-1800, 2010. Under suitable conditions, we show that if the ratio of the main chemoreceptors of individual cells, namely Tar/Tsr is less than a specific threshold, the bacteria move to the gradient of serine, and if the ratio is greater than the threshold, the group of bacteria move toward the gradient of MeAsp. Finally, we examine the theory with Monte-Carlo agent-based simulations, and verify that our results qualitatively agree well with the experimental results in Y. Kalinin et al. (2010).

Full work available at URL: https://arxiv.org/abs/2006.00688

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zbMATH Keywords

chemotaxisFokker-Planck equationspopulation dynamicsadvection-diffusion equationsMonte Carlo simulationsmulti-scale dynamicsintracellular decision making

Mathematics Subject Classification ID

Population dynamics (general) (92D25) Fokker-Planck equations (35Q84) Cell movement (chemotaxis, etc.) (92C17) Microbiology (92C70)

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Cited In (10)

• Theoretical results for chemotactic response and drift of \textit{E. coli} in a weak attractant gradient
• Sensitivity of the rate of nutrient uptake by chemotactic bacteria to physical and biological parameters in a turbulent environment
• Information and metabolism in bacterial chemotaxis
• A multi-scale model of \textit{Escherichia coli} chemotaxis from intracellular signaling pathway to motility and nutrient uptake in nutrient gradient and isotropic fluid environments
• Molecular and functional aspects of bacterial chemotaxis
• A mathematical description of bacterial chemotaxis in response to two stimuli
• Biological systems: reliable functions out of randomness
• A model of strongly biased chemotaxis reveals the trade-offs of different bacterial migration strategies
• A simple expression for quantifying bacterial chemotaxis using capillary assay data: Application to the analysis of enhanced chemotactic responses from growth-limited cultures
• Overview of mathematical approaches used to model bacterial chemotaxis. I: The single cell

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