Posterior analysis of n in the binomial (n,p) problem with both parameters unknown -- with applications to quantitative nanoscopy

DOI10.1214/21-AOS2096MaRDI QIDQ2073722zbMATH OpenFDO

Authors Laura Fee Schneider, Thomas Staudt, Andrea Krajina, Timo Aspelmeier, Axel Munk, Johannes Schmidt-Hieber

Publication date 7 February 2022

Published in The Annals of Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1809.02443

zbMATH Keywords

binomial distributionBayesian estimationposterior contractionBernstein-von Mises theorembeta-binomial likelihoodquantitative cell imaging

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Bayesian inference (62F15) Nonparametric estimation (62G05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of statistics to physics (62P35)

Abstract: Estimation of the population size $n$ from $k$ i.i.d. binomial observations with unknown success probability $p$ is relevant to a multitude of applications and has a long history. Without additional prior information this is a notoriously difficult task when $p$ becomes small, and the Bayesian approach becomes particularly useful. For a large class of priors, we establish posterior contraction and a Bernstein-von Mises type theorem in a setting where $pightarrow0$ and $nightarrowinfty$ as $koinfty$. Furthermore, we suggest a new class of Bayesian estimators for $n$ and provide a comprehensive simulation study in which we investigate their performance. To showcase the advantages of a Bayesian approach on real data, we also benchmark our estimators in a novel application from super-resolution microscopy.

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Cited in

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• Posterior consistency in the binomial model with unknown parameters: a numerical study

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