Information content of high-order associations of the human gut microbiota network

DOI10.1214/21-AOAS1449MaRDI QIDQ2078293zbMATH OpenFDO

Authors Yanyan Li

Publication date 28 February 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2005.08107

zbMATH Keywords

informationrelative entropyecosystemgut microbiotahigh-order associations

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: The human gastrointestinal tract is an environment that hosts an ecosystem of microorganisms essential to human health. Vital biological processes emerge from fundamental inter- and intra-species molecular interactions that influence the assembly and composition of the gut microbiota ecology. Here we quantify the complexity of the ecological relationships within the human infant gut microbiota ecosystem as a function of the information contained in the nonlinear associations of a sequence of increasingly-specified maximum entropy representations of the system. Our paradigm frames the ecological state, in terms of the presence or absence of individual microbial ecological units that are identified by amplicon sequence variants (ASV) in the gut microenvironment, as a function of both the ecological states of its neighboring units and, in a departure from standard graphical model representations, the associations among the units within its neighborhood. We characterize the order of the system based on the relative quantity of statistical information encoded by high-order statistical associations of the infant gut microbiota.

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Cites work

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Cited in

(1)

• Enterotype-like microbiome stratification as emergent structure in complex adaptive systems: a mathematical model

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• DADA2

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