Optimal control in pharmacokinetic drug administration

DOI10.3934/MBE.2022249MaRDI QIDQ2086908zbMATH OpenOpenAlexFDO

Authors Norbert Hungerbühler

Publication date 26 October 2022

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/mbe.2022249

zbMATH Keywords

drug administrationLaplace transformoptimal controlpharmacokinetics

Mathematics Subject Classification ID

Existence theories for optimal control problems involving ordinary differential equations (49J15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Cites work

• Inequality Constraints in the Calculus of Variations
• OptiDose: computing the individualized optimal drug dosing regimen using optimal control
• Optimal control
• Optimal control applied to biological models.
• Optimal control for a mathematical model for chemotherapy with pharmacometrics
• Optimal control with engineering applications.

Cited in

(4)

• Model-based control algorithm for medication dosing under incomplete information about the state of the organism
• Optimal drug dosage subject to constraints
• Optimal adaptive control of drug dosing using integral reinforcement learning
• Asymptotic stability and optimal control for a stochastic two-compartment pharmacokinetic model

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