OptiDose: computing the individualized optimal drug dosing regimen using optimal control

DOI10.1007/S10957-021-01819-WMaRDI QIDQ2032019zbMATH OpenOpenAlexFDO

Authors Freya Bachmann, Gilbert Koch, Marc Pfister, Gabor Szinnai, Johannes Schropp

Publication date 15 June 2021

Published in Journal of Optimization Theory and Applications (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/s10957-021-01819-w

zbMATH Keywords

model predictive controloptimal controlquasi-Newton methodspharmacokinetic-pharmacodynamic modelsindividualized optimal drug dosing

Mathematics Subject Classification ID

Medical applications (general) (92C50) Newton-type methods (49M15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Model predictive control (93B45)

Recommendations

• scientific article; zbMATH DE number 7599168
• Sufficient conditions for optimality for a mathematical model of drug treatment with pharmacodynamics
• Simulation of optimal infusion rate input. I
• Explicit and numerical methods for finding optimal therapeutics
• Optimal drug dosage subject to constraints

Cites work

• scientific article; zbMATH DE number 1274356 (Why is no real title available?)
• A tutorial on the deterministic impulse control maximum principle: necessary and sufficient optimality conditions
• An Introduction to Partial Differential Equations
• Bifurcation thresholds and optimal control in transmission dynamics of arboviral diseases
• Mathematical concepts in pharmacokinetics and pharmacodynamics with application to tumor growth
• Nonlinear model predictive control. Theory and algorithms.
• Optimal EPO dosing in hemodialysis patients using a non-linear model predictive control approach
• Optimal control for mathematical models of cancer therapies. An application of geometric methods
• Optimization with PDE Constraints

Cited in

(5)

• Model-based control algorithm for medication dosing under incomplete information about the state of the organism
• Optimal drug dosage subject to constraints
• Optimal control in pharmacokinetic drug administration
• scientific article; zbMATH DE number 7599168 (Why is no real title available?)
• Optimal adaptive control of drug dosing using integral reinforcement learning

Describes a project that uses

Uses Software

• KELLEY
• Matlab

This page was built for publication: OptiDose: computing the individualized optimal drug dosing regimen using optimal control

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2032019)