Aqueous humor dynamics in human eye: a lattice Boltzmann study

DOI10.3934/MBE.2021255MaRDI QIDQ2091968zbMATH OpenOpenAlexFDO

Authors Yanyan Li

Publication date 2 November 2022

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2102.12663

zbMATH Keywords

incompressible Navier-Stokes equationlattice Boltzmann methodDarcy equationconvection diffusion equationBoussinesq approximationaqueous humor dynamics

Mathematics Subject Classification ID

Navier-Stokes equations (35Q30) Physiological flow (92C35)

Abstract: This paper presents a lattice Boltzmann model to simulate the aqueous humor (AH) dynamics in the human eyes by involving incompressible Navier-Stokes flow, heat convection and diffusion, and Darcy seepage flow. Verifying simulations indicate that the model is stable, convergent and robust. Further investigations were carried out, including the effects of heat convection and buoyancy, AH production rate, permeability of trabecular meshwork, viscosity of AH and anterior chamber angle on intraocular pressure (IOP). The heat convection and diffusion can significantly affect the flow patterns in the healthy eye, and the IOP can be controlled by increasing the anterior chamber angle or decreasing the secretion rate, the drainage resistance and viscosity of AH. However, the IOP is insensitive to the viscosity of the AH, which may be one of the causes that the viscosity would not have been considered as a factor for controlling the IOP. It's interesting that all these factors have more significant influences on the IOP in pathologic eyes than healthy ones. The temperature difference and the eye-orientation have obvious influence on the cornea and iris wall shear stresses. The present model and simulation results are expected to provide an alternative tool and theoretical reference for the study of AH dynamics.

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