A tumor growth model with autophagy: the reaction-(cross-)diffusion system and its free boundary limit
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Publication:2099200
PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Finite difference methods for boundary value problems involving PDEs (65N06) Computational methods for problems pertaining to biology (92-08) Mathematical modeling or simulation for problems pertaining to biology (92-10) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
Abstract: In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients. First, we construct a reaction-(cross-)diffusion system describing the evolution of cell densities, where the drift is determined by the negative gradient of the joint pressure, and the reaction terms manifest the unique mechanism of autophagy. Next, in the incompressible limit, such a cell density model naturally connects to a free boundary system, describing the geometric motion of the tumor region. Analyzing the free boundary model in a special case, we show that the ratio of the two phases of cells exponentially converges to a ``well-mixed" limit. Within this ``well-mixed" limit, we obtain an analytical solution of the free boundary system which indicates the exponential growth of the tumor size in the presence of autophagy in contrast to the linear growth without it. Numerical simulations are also provided to illustrate the analytical properties and to explore more scenarios.
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Cited in
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