The Hele-Shaw asymptotics for mechanical models of tumor growth
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Publication:2453963
DOI10.1007/S00205-013-0704-YzbMATH Open1293.35347arXiv1301.2612OpenAlexW2083551379WikidataQ60502751 ScholiaQ60502751MaRDI QIDQ2453963FDOQ2453963
Authors: Fernando Quirós, Ben{ôı}t Perthame, Juan Luis Vázquez 
Publication date: 12 June 2014
Published in: Archive for Rational Mechanics and Analysis (Search for Journal in Brave)
Abstract: Models of tumor growth, now commonly used, present several levels of complexity, both in terms of the biomedical ingredients and the mathematical description. The simplest ones contain competition for space using purely fluid mechanical concepts. Another possible ingredient is the supply of nutrients through vasculature. The models can describe the tissue either at the level of cell densities, or at the scale of the solid tumor, in this latter case by means of a free boundary problem. Our first goal here is to formulate a free boundary model of Hele-Shaw type, a variant including growth terms, starting from the description at the cell level and passing to a certain limit. A detailed mathematical analysis of this purely mechanical model is performed. Indeed, we are able to prove strong convergence in passing to the limit, with various uniform gradient estimates; we also prove uniqueness for the asymptotic Hele-Shaw type problem. The main tools are nonlinear regularizing effects for certain porous medium type equations, regularization techniques `a la Steklov, and a Hilbert duality method for uniqueness. At variance with the classical Hele-Shaw problem, here the geometric motion governed by the pressure is not sufficient to completely describe the dynamics. A complete description requires the equation on the cell number density. Using this theory as a basis, we go on to consider the more complex model including nutrients. We obtain the equation for the limit of the coupled system; the method relies on some BV bounds and space/time a priori estimates. Here, new technical difficulties appear, and they reduce the generality of the results in terms of the initial data. Finally, we prove uniqueness for the system, a main mathematical difficulty.
Full work available at URL: https://arxiv.org/abs/1301.2612
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Medical applications (general) (92C50) Population dynamics (general) (92D25) Asymptotic behavior of solutions to PDEs (35B40) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Other free boundary flows; Hele-Shaw flows (76D27)
Cites Work
- The porous medium equation. Mathematical theory
- Title not available (Why is that?)
- Nonlinear modelling of cancer: bridging the gap between cells and tumours
- Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
- Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development
- ON THE FOUNDATIONS OF CANCER MODELLING: SELECTED TOPICS, SPECULATIONS, AND PERSPECTIVES
- Title not available (Why is that?)
- Title not available (Why is that?)
- Existence and uniqueness of a sharp travelling wave in degenerate non- linear diffusion Fisher-KPP equations
- Uniqueness and existence results on the Hele-Shaw and the Stefan problems
- A hierarchy of cancer models and their mathematical challenges
- Title not available (Why is that?)
- Limit behaviour of focusing solutions to nonlinear diffusions
- Growth of necrotic tumors in the presence and absence of inhibitors
- Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications
- Models for the Growth of a Solid Tumor by Diffusion
- Modelling solid tumour growth using the theory of mixtures
- Stability and instability of Liapunov-Schmidt and Hopf bifurcation for a free boundary problem arising in a tumor model
- Traveling Wave Solutions to Combustion Models and Their Singular Limits
- Individual-based and continuum models of growing cell populations: a comparison
- A variational inequality approach to Hele-Shaw flow with a moving boundary
- Formation of necrotic cores in the growth of tumors: analytic results
- Asymptotic Behaviour of Solutions of a Multidimensional Moving Boundary Problem Modeling Tumor Growth
- A mean field equation as limit of nonlinear diffusions with fractional Laplacian operators
- The Ill-Posed Hele-Shaw Model and The Stefan Problem for Supercooled Water
- Continuous dependence estimates for viscosity solutions of fully nonlinear degenerate parabolic equations
- Global existence and decay for solutions of the Hele-Shaw flow with injection
- Homogenization of a Hele-Shaw problem in periodic and random media
- On the Weak Solution of Moving Boundary Problems
- A singular limit problem for the porous medium equation
- Boundary layer formation in the transition from the porous media equation to a Hele-Shaw flow.
- The Mesa Problem: Diffusion Patterns for ut = ∇ · (um∇u) as m → +∞
- Composite waves for a cell population system modeling tumor growth and invasion
- The mesa-limit of the porous-medium equation and the Hele-Shaw problem
- On the Mesa problem
- Title not available (Why is that?)
- Ablative Hele-Shaw model for ICF flows modeling and numerical simulation
- Convergence of the porous media equation to Hele-Shaw
- The Hele-Shaw problem as a ‘‘Mesa” limit of Stefan problems: Existence, uniqueness, and regularity of the free boundary
Cited In (only showing first 100 items - show all)
- A tumor growth model with autophagy: the reaction-(cross-)diffusion system and its free boundary limit
- Compression effects in heterogeneous media
- Bridging the gap between individual-based and continuum models of growing cell populations
- Primal dual methods for Wasserstein gradient flows
- Darcy's law with a source term
- Interface dynamics in a two-phase tumor growth model
- The Aronson-Bénilan estimate in Lebesgue spaces
- Crowd motion and evolution PDEs under density constraints
- Existence and uniqueness of global classical solutions to a two dimensional two species cancer invasion haptotaxis model
- Free boundary problems for tumor growth: a viscosity solutions approach
- Nonlinear simulation of an elastic tumor-host interface
- Free/Congested Two-Phase Model from Weak Solutions to Multi-Dimensional Compressible Navier-Stokes Equations
- A density-constrained model for chemotaxis
- Traveling wave solution of the Hele-Shaw model of tumor growth with nutrient
- Logarithmic corrections in Fisher-KPP type porous medium equations
- Models of cell motion and tissue growth
- Discrete and continuum models for the evolutionary and spatial dynamics of cancer: a very short introduction through two case studies
- Free boundary problems with surface tension conditions
- From individual-based mechanical models of multicellular systems to free-boundary problems
- Scaling algorithms for unbalanced optimal transport problems
- Incompressible limit of a continuum model of tissue growth for two cell populations
- Transversal instability for the thermodiffusive reaction-diffusion system
- Uniform convergence for the incompressible limit of a tumor growth model
- The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
- Aggregation-diffusion equations: dynamics, asymptotics, and singular limits
- A phenotype-structured model to reproduce the avascular growth of a tumor and its interaction with the surrounding environment
- Hele-Shaw limit for a system of two reaction-(Cross-)diffusion equations for living tissues
- Coupled bulk-surface free boundary problems arising from a mathematical model of receptor-ligand dynamics
- A structure-preserving, operator splitting scheme for reaction-diffusion equations with detailed balance
- Invasion fronts and adaptive dynamics in a model for the growth of cell populations with heterogeneous mobility
- Mathematical analysis of some multi-dimensional tissue-growth models
- On nonlinear cross-diffusion systems: an optimal transport approach
- Multi-species viscous models for tissue growth: incompressible limit and qualitative behaviour
- A new continuum theory for incompressible swelling materials
- Convergence Analysis of the Variational Operator Splitting Scheme for a Reaction-Diffusion System with Detailed Balance
- Existence of Solutions to Reaction Cross Diffusion Systems
- Incompressible limit of a continuum model of tissue growth with segregation for two cell populations
- Incompressible limit for a two-species model with coupling through Brinkman's law in any dimension
- Derivation of a Hele-Shaw type system from a cell model with active motion
- Modelling of phase transitions in granular flows
- A Hele-Shaw problem for tumor growth
- Incompressible limit of the Navier-Stokes model with a growth term
- Composite waves for a cell population system modeling tumor growth and invasion
- A JKO splitting scheme for Kantorovich-Fisher-Rao gradient flows
- Bound preserving and energy dissipative schemes for porous medium equation
- Analysis and computation of some tumor growth models with nutrient: from cell density models to free boundary dynamics
- A two-species hyperbolic-parabolic model of tissue growth
- Singular limit of the generalized Burgers equation with absorption
- Incompressible limit for a two-species tumour model with coupling through Brinkman's law in one dimension
- On Lagrangian schemes for porous medium type generalized diffusion equations: a discrete energetic variational approach
- From short-range repulsion to Hele-Shaw problem in a model of tumor growth
- Modeling the chemotherapy-induced selection of drug-resistant traits during tumor growth
- Local and global existence of solutions to a quasilinear degenerate chemotaxis system with unbounded initial data
- A tractable mathematical model for tissue growth
- A Hele-Shaw limit without monotonicity
- Aggregation-diffusion to constrained interaction: minimizers \& gradient flows in the slow diffusion limit
- Incompressible limit of a mechanical model of tumour growth with viscosity
- Singular limit of the porous medium equation with a drift
- Free boundary limit of a tumor growth model with nutrient
- Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
- Optimal transport in competition with reaction: the Hellinger-Kantorovich distance and geodesic curves
- An unbalanced optimal transport splitting scheme for general advection-reaction-diffusion problems
- Incompressible limit of a mechanical model for tissue growth with non-overlapping constraint
- Modelling skin wound healing angiogenesis: a review
- An accurate front capturing scheme for tumor growth models with a free boundary limit
- On interfaces between cell populations with different mobilities
- Tumor growth with nutrients: Regularity and stability
- Tumor Growth with Nutrients: Stability of the Tumor Patches
- Porous medium equation to Hele-Shaw flow with general initial density
- Toward understanding the boundary propagation speeds in tumor growth models
- Existence and incompressible limit of a tissue growth model with autophagy
- Traveling waves for the Keller-Segel-FKPP equation with strong chemotaxis
- Degenerate Cahn-Hilliard equation: from nonlocal to local
- Tumor growth with a necrotic core as an obstacle problem in pressure
- A Second-Order Accurate, Operator Splitting Scheme for Reaction-Diffusion Systems in an Energetic Variational Formulation
- The impact of competition between cancer cells and healthy cells on optimal drug delivery
- Derivation and analysis of a nonlocal Hele-Shaw-Cahn-Hilliard system for flow in thin heterogeneous layers
- A tumor growth model of Hele-Shaw type as a gradient flow
- The Stefan problem and free targets of optimal Brownian martingale transport
- A Hele–Shaw Limit with a Variable Upper Bound and Drift
- Tumor boundary instability induced by nutrient consumption and supply
- Maximal regularity and optimal control for a non-local Cahn-Hilliard tumour growth model
- Fine properties of geodesics and geodesic \(\lambda\)-convexity for the Hellinger-Kantorovich distance
- Incompressible limits of the Patlak-Keller-Segel model and its stationary state
- Stress‐modulated growth in the presence of nutrients—Existence and uniqueness in one spatial dimension
- Applications of optimal transportation. Abstracts from the workshop held February 4--9, 2024
- Speed-up of traveling waves by negative chemotaxis
- A Degenerate Cross-Diffusion System as the Inviscid Limit of a Nonlocal Tissue Growth Model
- On the incompressible limit for a tumour growth model incorporating convective effects
- Porous medium type reaction-diffusion equation: large time behaviors and regularity of free boundary
- An asymptotic preserving scheme for a tumor growth model of porous medium type
- Incompressible Limit of a Porous Media Equation with Bistable and Monostable Reaction Term
- Regularity of Hele-Shaw flow with source and drift
- High order spatial discretization for variational time implicit schemes: Wasserstein gradient flows and reaction-diffusion systems
- Mean field limit for congestion dynamics
- Convergence rate for the incompressible limit of nonlinear diffusion-advection equations
- \(L^1\)-theory for incompressible limit of reaction-diffusion porous medium flow with linear drift
- Phenotypic heterogeneity in a model of tumour growth: existence of solutions and incompressible limit
- Effective interface conditions for a porous medium type problem
- A mixture-like model for tumor-immune system interactions
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