An asymptotic preserving scheme for a tumor growth model of porous medium type

DOI10.1051/M2AN/2021080MaRDI QIDQ5034776zbMATH OpenOpenAlexFDO

Authors Noemi David, Xinran Ruan

Publication date 21 February 2022

Published in ESAIM: Mathematical Modelling and Numerical Analysis (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/2105.10376

zbMATH Keywords

finite difference methodincompressible limitporous medium equationasymptotic preserving schemeHele-Shaw problemfocusing solution

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Degenerate parabolic equations (35K65) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Stability and convergence of numerical methods for initial value and initial-boundary value problems involving PDEs (65M12) Pathology, pathophysiology (92C32)

Abstract: Mechanical models of tumor growth based on a porous medium approach have been attracting a lot of interest both analytically and numerically. In this paper, we study the stability properties of a finite difference scheme for a model where the density evolves down pressure gradients and the growth rate depends on the pressure and possibly nutrients. Based on the stability results, we prove the scheme to be asymptotic preserving (AP) in the incompressible limit. Numerical simulations are performed in order to investigate the regularity of the pressure. We study the sharpness of the $L^4$-uniform bound of the gradient, the limiting case being a solution whose support contains a bubble which closes-up in finite time generating a singularity, the so-called focusing solution.

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Cited in

(2)

• Convergence rate for the incompressible limit of nonlinear diffusion-advection equations
• A convergent explicit finite difference scheme for a mechanical model for tumor growth

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