Derivation of a Hele-Shaw type system from a cell model with active motion

DOI10.4171/IFB/327zbMATH Open1325.35092arXiv1401.2816OpenAlexW2150631118WikidataQ60502743 ScholiaQ60502743MaRDI QIDQ2255307FDOQ2255307

Nicholas Vauchelet, Fernando Quirós, Min Tang, Ben{ôı}t Perthame

Publication date: 9 February 2015

Published in: Interfaces and Free Boundaries (Search for Journal in Brave)

Abstract: We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is considered here as a standard diffusion process. The free boundary model is derived from a description at the cell level using the asymptotic of a stiff pressure limit. Compared to the case when active motion is neglected, the pressure satisfies the same complementarity Hele-Shaw type formula. However, the cell density is smoother (Lipschitz continuous), while there is a deep change in the free boundary velocity, which is no longer given by the gradient of the pressure, because some kind of 'mushy region' prepares the tumor invasion.

Full work available at URL: https://arxiv.org/abs/1401.2816

Recommendations

• The Hele-Shaw asymptotics for mechanical models of tumor growth
• A Hele-Shaw problem for tumor growth
• Free boundary problems for tumor growth: a viscosity solutions approach
• Porous medium equation to Hele-Shaw flow with general initial density
• From a cell model with active motion to a Hele-Shaw-like system: a numerical approach

zbMATH Keywords

diffusiondensity smoothnesstumor-growth models

Mathematics Subject Classification ID

Medical applications (general) (92C50) Singular perturbations in context of PDEs (35B25) Nonlinear parabolic equations (35K55) Free boundary problems for PDEs (35R35) Other free boundary flows; Hele-Shaw flows (76D27)

Cited In (24)

• Aggregation-Diffusion Equations: Dynamics, Asymptotics, and Singular Limits
• Bridging the gap between individual-based and continuum models of growing cell populations
• The Aronson-Bénilan estimate in Lebesgue spaces
• Free boundary problems for tumor growth: a viscosity solutions approach
• A New Continuum Theory for Incompressible Swelling Materials
• Convex dynamics in Hele-Shaw cells
• Existence and Incompressible Limit of a Tissue Growth Model with Autophagy
• A two-species hyperbolic–parabolic model of tissue growth
• From individual-based mechanical models of multicellular systems to free-boundary problems
• Incompressible limit of a continuum model of tissue growth for two cell populations
• Hele-Shaw limit for a system of two reaction-(Cross-)diffusion equations for living tissues
• From a cell model with active motion to a Hele-Shaw-like system: a numerical approach
• Incompressible limit of a continuum model of tissue growth with segregation for two cell populations
• On the incompressible limit for a tumour growth model incorporating convective effects
• Incompressible limit for a two-species model with coupling through Brinkman's law in any dimension
• Incompressible limit of the Navier-Stokes model with a growth term
• An asymptotic preserving scheme for a tumor growth model of porous medium type
• Incompressible Limit of a Porous Media Equation with Bistable and Monostable Reaction Term
• Incompressible limit for a two-species tumour model with coupling through Brinkman's law in one dimension
• From short-range repulsion to Hele-Shaw problem in a model of tumor growth
• Incompressible limit of a mechanical model of tumour growth with viscosity
• Phenotypic heterogeneity in a model of tumour growth: existence of solutions and incompressible limit
• On interfaces between cell populations with different mobilities
• Porous medium equation to Hele-Shaw flow with general initial density

This page was built for publication: Derivation of a Hele-Shaw type system from a cell model with active motion

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2255307)