Derivation of a Hele-Shaw type system from a cell model with active motion
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Publication:2255307
Abstract: We formulate a Hele-Shaw type free boundary problem for a tumor growing under the combined effects of pressure forces, cell multiplication and active motion, the latter being the novelty of the present paper. This new ingredient is considered here as a standard diffusion process. The free boundary model is derived from a description at the cell level using the asymptotic of a stiff pressure limit. Compared to the case when active motion is neglected, the pressure satisfies the same complementarity Hele-Shaw type formula. However, the cell density is smoother (Lipschitz continuous), while there is a deep change in the free boundary velocity, which is no longer given by the gradient of the pressure, because some kind of 'mushy region' prepares the tumor invasion.
The paper addresses a modification of a mathematical model of the tumor growth of the Hele-Shaw type. In addition to previously studied ingredients, active motion of cancer cells is taken into regard. The results demonstrate a smoother pattern of the cell density, and elucidate how the mobility of the cells facilitates tumor invasion of healthy tissues.
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