A unified term for directed and undirected motility in collective cell invasion

DOI10.1016/J.AML.2012.06.015MaRDI QIDQ714577zbMATH OpenOpenAlexFDO

Authors Jason M. Graham, Bruce P. Ayati

Publication date 11 October 2012

Published in Applied Mathematics Letters (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1203.4993

zbMATH Keywords

cell motilitynonlinear diffusiontumor

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

Abstract: In this paper we develop mathematical models for collective cell motility. Initially we develop a model using a linear diffusion-advection type equation and fit the parameters to data from cell motility assays. This approach is helpful in classifying the results of cell motility assay experiments. In particular, this model can determine degrees of directed versus undirected collective cell motility. Next we develop a model using a nonlinear diffusion term that is able capture in a unified way directed and undirected collective cell motility. Finally we apply the nonlinear diffusion approach to a problem in tumor cell invasion, noting that neither chemotaxis or haptotaxis are present in the system under consideration in this article.

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Cites work

• scientific article; zbMATH DE number 3934831 (Why is no real title available?)
• A one-dimensional model of cell diffusion and aggregation, incorporating volume filling and cell-to-cell adhesion
• A unified term for directed and undirected motility in collective cell invasion
• Distinguishing between directed and undirected cell motility within an invading cell population
• Mathematics of cell motility: Have we got its number?
• \(M^5\) mesoscopic and macroscopic models for mesenchymal motion

Cited in

(7)

• Mini-workshop: PDE models of motility and invasion in active biosystems. Abstracts from the mini-workshop held October 22--28, 2017
• Hole-closing model reveals exponents for nonlinear degenerate diffusivity functions in cell biology
• Modelling collective cell motion in biology
• A unified term for directed and undirected motility in collective cell invasion
• An efficient implicit spectral element method for time-dependent nonlinear diffusion equations by evaluating integrals at one quadrature point
• Distinguishing between directed and undirected cell motility within an invading cell population
• Mathematical and numerical analysis of an acid-mediated cancer invasion model with nonlinear diffusion

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