A unified term for directed and undirected motility in collective cell invasion
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Publication:714577
DOI10.1016/J.AML.2012.06.015zbMATH Open1388.92006arXiv1203.4993OpenAlexW2105862411MaRDI QIDQ714577FDOQ714577
Authors: Jason M. Graham, Bruce P. Ayati 
Publication date: 11 October 2012
Published in: Applied Mathematics Letters (Search for Journal in Brave)
Abstract: In this paper we develop mathematical models for collective cell motility. Initially we develop a model using a linear diffusion-advection type equation and fit the parameters to data from cell motility assays. This approach is helpful in classifying the results of cell motility assay experiments. In particular, this model can determine degrees of directed versus undirected collective cell motility. Next we develop a model using a nonlinear diffusion term that is able capture in a unified way directed and undirected collective cell motility. Finally we apply the nonlinear diffusion approach to a problem in tumor cell invasion, noting that neither chemotaxis or haptotaxis are present in the system under consideration in this article.
Full work available at URL: https://arxiv.org/abs/1203.4993
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Cites Work
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- Mathematics of cell motility: Have we got its number?
- Distinguishing between directed and undirected cell motility within an invading cell population
- A unified term for directed and undirected motility in collective cell invasion
Cited In (4)
- Mathematical and numerical analysis of an acid-mediated cancer invasion model with nonlinear diffusion
- An efficient implicit spectral element method for time-dependent nonlinear diffusion equations by evaluating integrals at one quadrature point
- A unified term for directed and undirected motility in collective cell invasion
- Distinguishing between directed and undirected cell motility within an invading cell population
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