A tractable mathematical model for tissue growth

DOI10.4171/IFB/428zbMATH Open1442.35557arXiv1907.06590OpenAlexW2995727281MaRDI QIDQ2295751FDOQ2295751

Joe Eyles, J. R. King, Vanessa Styles

Publication date: 14 February 2020

Published in: Interfaces and Free Boundaries (Search for Journal in Brave)

Abstract: Using formal asymptotic methods we derive a free boundary problem representing one of the simplest mathematical descriptions of the growth and death of a tumour or other biological tissue. The mathematical model takes the form of a closed interface evolving via forced mean curvature flow (together with a `kinetic under-cooling' regularisation) where the forcing depends on the solution of a PDE that holds in the domain enclosed by the interface. We perform linear stability analysis and derive a diffuse-interface approximation of the model. Finite-element discretisations of two closely related models are presented, together with computational results comparing the approximate solutions.

Full work available at URL: https://arxiv.org/abs/1907.06590

zbMATH Keywords

finite elementsdiffuse interface modeltissue growthforced mean curvature flowformal asymptotic methods

Mathematics Subject Classification ID

Biomechanical solid mechanics (74L15) Physiology (general) (92C30) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Free boundary problems for PDEs (35R35) Moving boundary problems for PDEs (35R37) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) General biology and biomathematics (92B05) Flows related to mean curvature (53E10)

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Cited In (16)

• Numerical analysis for a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport
• Mathematical characterization and identification of remodeling, growth, aging and morphogenesis
• A convergent algorithm for forced mean curvature flow driven by diffusion on the surface
• Title not available (Why is that?)
• The emergence of complexity from a simple model for tissue growth
• Interfaces, free boundaries and geometric partial differential equations. Abstracts from the workshop held February 11--16, 2024
• Travelling-wave and asymptotic analysis of a multiphase moving boundary model for engineered tissue growth
• Multi-species viscous models for tissue growth: incompressible limit and qualitative behaviour
• Numerical analysis for the interaction of mean curvature flow and diffusion on closed surfaces
• Incompressible limit for a two-species model with coupling through Brinkman's law in any dimension
• Numerical simulation of anisotropic tissue growth using a total Lagrangian formulation
• Cahn-Hilliard-Brinkman systems for tumour growth
• A qualitative analysis of some models of tissue growth
• A theoretical model for tissue growth in confined geometries
• Finite-element approximation of a phase field model for tumour growth
• Free boundary problems for Stokes flow, with applications to the growth of biological tissues

Uses Software

• Gmsh

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