A Cahn-Hilliard-Darcy model for tumour growth with chemotaxis and active transport

DOI10.1142/S0218202516500263zbMATH Open1336.92038arXiv1508.00437OpenAlexW2594425100MaRDI QIDQ2806548FDOQ2806548

Harald Garcke, Kei Fong Lam, Vanessa Styles, Emanuel Sitka

Publication date: 18 May 2016

Published in: M\(^3\)AS. Mathematical Models \& Methods in Applied Sciences (Search for Journal in Brave)

Abstract: Using basic thermodynamic principles we derive a Cahn--Hilliard--Darcy model for tumour growth including nutrient diffusion, chemotaxis, active transport, adhesion, apoptosis and proliferation. The model generalises earlier models and in particular includes active transport mechanisms which ensure thermodynamic consistency. We perform a formally matched asymptotic expansion and develop several sharp interface models. Some of them are classical and some are new which for example include a jump in the nutrient density at the interface. A linear stability analysis for a growing nucleus is performed and in particular the role of the new active transport term is analysed. Numerical computations are performed to study the influence of the active transport term for specific growth scenarios.

Full work available at URL: https://arxiv.org/abs/1508.00437

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zbMATH Keywords

Cahn-Hilliard equationchemotaxisstability analysisdiffuse interface modeltumour growthmatched asymptotic expansionsDarcy's flowfinite element computations

Mathematics Subject Classification ID

Medical applications (general) (92C50) Reaction-diffusion equations (35K57) Free boundary problems for PDEs (35R35) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Cell movement (chemotaxis, etc.) (92C17)

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Cited In (only showing first 100 items - show all)

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Uses Software

• ALBERTA

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