Long-time dynamics and optimal control of a diffuse interface model for tumor growth
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Publication:2020308
DOI10.1007/S00245-019-09562-5zbMATH Open1464.35357arXiv1901.07500OpenAlexW2913832872MaRDI QIDQ2020308FDOQ2020308
Authors: Cecilia Cavaterra, Elisabetta Rocca, Hao Wu 
Publication date: 23 April 2021
Published in: Applied Mathematics and Optimization (Search for Journal in Brave)
Abstract: We investigate the long-time dynamics and optimal control problem of a diffuse interface model that describes the growth of a tumor in presence of a nutrient and surrounded by host tissues. The state system consists of a Cahn-Hilliard type equation for the tumor cell fraction and a reaction-diffusion equation for the nutrient. The possible medication that serves to eliminate tumor cells is in terms of drugs and is introduced into the system through the nutrient. In this setting, the control variable acts as an external source in the nutrient equation. First, we consider the problem of `long-time treatment' under a suitable given source and prove the convergence of any global solution to a single equilibrium as . Then we consider the `finite-time treatment' of a tumor, which corresponds to an optimal control problem. Here we also allow the objective cost functional to depend on a free time variable, which represents the unknown treatment time to be optimized. We prove the existence of an optimal control and obtain first order necessary optimality conditions for both the drug concentration and the treatment time. One of the main aim of the control problem is to realize in the best possible way a desired final distribution of the tumor cells, which is expressed by the target function . By establishing the Lyapunov stability of certain equilibria of the state system (without external source), we see that can be taken as a stable configuration, so that the tumor will not grow again once the finite-time treatment is completed.
Full work available at URL: https://arxiv.org/abs/1901.07500
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Cahn-Hilliard equationlong-time behavioroptimal controlreaction-diffusion equationtumor growthLyapunov stability
Medical applications (general) (92C50) Stability in context of PDEs (35B35) Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Applications of optimal control and differential games (49N90) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
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