Optimal control of treatment time in a diffuse interface model of tumor growth

DOI10.1007/s00245-017-9414-4zbMath1403.35139arXiv1608.00488OpenAlexW2963768558MaRDI QIDQ1630417

Kei Fong Lam, Harald Garcke, Elisabetta Rocca

Publication date: 10 December 2018

Published in: Applied Mathematics and Optimization (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1608.00488

zbMATH Keywords

tumor growthwell-posednessCahn-Hilliard equationfree terminal timedistributed optimal controlcancer treatment

Mathematics Subject Classification ID

Optimality conditions for problems involving partial differential equations (49K20) Medical applications (general) (92C50) Cell biology (92C37) Existence theories for optimal control problems involving partial differential equations (49J20) Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61)

Related Items

Existence of weak solutions to multiphase Cahn–Hilliard–Darcy and Cahn–Hilliard–Brinkman models for stratified tumor growth with chemotaxis and general source terms ⋮ Long time dynamics of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects ⋮ Analysis of a tumor model as a multicomponent deformable porous medium ⋮ Well-posedness for a class of phase-field systems modeling prostate cancer growth with fractional operators and general nonlinearities ⋮ Analysis of general shape optimization problems in nonlinear acoustics ⋮ Optimal control problems with sparsity for tumor growth models involving variational inequalities ⋮ Optimal distributed control of the Cahn-Hilliard-Brinkman system with regular potential ⋮ On the long time behavior of a tumor growth model ⋮ Tumor evolution models of phase-field type with nonlocal effects and angiogenesis ⋮ On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: insights from a mathematical model ⋮ Sliding mode control for a phase field system related to tumor growth ⋮ Optimal control of a model for brain lactate kinetics ⋮ On an optimal control problem describing lactate production inhibition ⋮ Optimal control of an Allen-Cahn model for tumor growth through supply of cytotoxic drugs ⋮ On the viscous Cahn–Hilliard–Oono system with chemotaxis and singular potential ⋮ Optimal distributed control for a viscous non-local tumour growth model ⋮ Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme ⋮ Well-posedness and optimal control for a viscous Cahn-Hilliard-Oono system with dynamic boundary conditions ⋮ Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential ⋮ Optimal control theory and advanced optimality conditions for a diffuse interface model of tumor growth ⋮ Mathematical analysis and simulation study of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects ⋮ Refined existence and regularity results for a class of semilinear dissipative SPDEs ⋮ Nonlocal-to-local convergence of Cahn-Hilliard equations: Neumann boundary conditions and viscosity terms ⋮ Spatial patterns and bifurcation analysis of a diffusive tumour-immune model ⋮ Asymptotic analysis of a tumor growth model with fractional operators ⋮ Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth ⋮ Optimal medication for tumors modeled by a Cahn-Hilliard-Brinkman equation ⋮ Long-time dynamics and optimal control of a diffuse interface model for tumor growth ⋮ Existence and bifurcation of non-constant positive steady states for a tumor-immune model ⋮ Penalisation of long treatment time and optimal control of a tumour growth model of Cahn-Hilliard type with singular potential ⋮ Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials ⋮ The stochastic viscous Cahn-Hilliard equation: well-posedness, regularity and vanishing viscosity limit ⋮ Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis ⋮ Optimality conditions for an extended tumor growth model with double obstacle potential via deep quench approach ⋮ Inverse problem for a Cahn–Hilliard type system modeling tumor growth ⋮ Time-fractional Cahn-Hilliard equation: well-posedness, degeneracy, and numerical solutions ⋮ On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport ⋮ Parameter identification via optimal control for a Cahn-Hilliard-chemotaxis system with a variable mobility ⋮ Well-posedness and optimal control for a Cahn-Hilliard-Oono system with control in the mass term ⋮ Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth ⋮ Optimal control of stochastic phase-field models related to tumor growth ⋮ Sparse Optimal Control of a Phase Field Tumor Model with Mechanical Effects ⋮ Numerical analysis for a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport ⋮ Parameter identification for nonlocal phase field models for tumor growth via optimal control and asymptotic analysis

Cites Work

• Unnamed Item
• Unnamed Item
• Unnamed Item
• Unnamed Item
• Unnamed Item
• Unnamed Item
• On a Cahn-Hilliard type phase field system related to tumor growth
• Free terminal time optimal control problem of an HIV model based on a conjugate gradient method
• A boundary control problem for the viscous Cahn-Hilliard equation with dynamic boundary conditions
• Optimal control of the sixth-order convective Cahn-Hilliard equation
• Asymptotic analyses and error estimates for a Cahn-Hilliard type phase field system modelling tumor growth
• Analysis of a Cahn-Hilliard system with non-zero Dirichlet conditions modeling tumor growth with chemotaxis
• Optimal control problem for viscous Cahn-Hilliard equation
• Optimal control for the convective Cahn-Hilliard equation in 2D case
• On the Cahn-Hilliard-Brinkman system
• A boundary control problem for the pure Cahn-Hilliard equation with dynamic boundary conditions
• Vanishing viscosities and error estimate for a Cahn-Hilliard type phase field system related to tumor growth
• Compact sets in the space \(L^ p(0,T;B)\)
• Pontryagin's principle for time-optimal problems
• Time optimal problems with Dirichlet boundary controls
• Elliptic partial differential equations of second order
• Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
• Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
• Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching
• Well-posedness and long-time behavior of a non-autonomous Cahn-Hilliard-Darcy system with mass source modeling tumor growth
• Bayesian calibration, validation, and uncertainty quantification of diffuse interface models of tumor growth
• Optimal Distributed Control of a Nonlocal Cahn--Hilliard/Navier--Stokes System in Two Dimensions
• A Cahn–Hilliard–Darcy model for tumour growth with chemotaxis and active transport
• Optimal control of the convective Cahn–Hilliard equation
• Analysis of a mixture model of tumor growth
• Distributed Optimal Control of the Cahn–Hilliard System Including the Case of a Double-Obstacle Homogeneous Free Energy Density
• Numerical simulation of a thermodynamically consistent four-species tumor growth model
• Optimal Boundary Control of a Viscous Cahn--Hilliard System with Dynamic Boundary Condition and Double Obstacle Potentials
• Optimization with PDE Constraints
• GENERAL DIFFUSE-INTERFACE THEORIES AND AN APPROACH TO PREDICTIVE TUMOR GROWTH MODELING
• A note on the free terminal time transversality condition
• On a diffuse interface model of tumour growth
• Well-posedness of a Cahn–Hilliard system modelling tumour growth with chemotaxis and active transport
• Analysis of a diffuse interface model of multispecies tumor growth
• Optimal distributed control of a diffuse interface model of tumor growth
• Optimal Control of a Semidiscrete Cahn--Hilliard--Navier--Stokes System
• Optimal Distributed Control of a Nonlocal Convective Cahn--Hilliard Equation by the Velocity in Three Dimensions
• Second-order analysis of a boundary control problem for the viscous Cahn--Hilliard equation with dynamic boundary condition
• Nonlinear partial differential equations with applications
• Time optimal problems with boundary controls