Optimal control of a model for brain lactate kinetics

DOI10.3233/ASY-221823MaRDI QIDQ6094865zbMATH OpenFDO

Authors Hussein Raad, Laurence Cherfils, C. Allery, Rémy Guillevin

Publication date 14 September 2023

Published in Asymptotic Analysis (Search for Journal in Brave)

Full work available at URL https://doi.org/10.3233/ASY-221823

zbMATH Keywords

adjoint equationsCahn-Hilliard equationFréchet differentiability with respect to the controllactate kineticsnumerical simulationsoptimal controlwell-posedness

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) A priori estimates in context of PDEs (35B45) Weak solutions to PDEs (35D30) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

• Analysis of a mathematical model for brain lactate kinetics
• Analysis of a model for tumor growth and lactate exchanges in a glioma
• Cahn-Hilliard models for glial cells
• Numerical optimization. Theoretical and practice aspects
• On a tumor growth model with brain lactate kinetics
• On an optimal control problem describing lactate production inhibition
• Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth
• Optimal control of treatment time in a diffuse interface model of tumor growth
• Optimal distributed control of an extended model of tumor growth with logarithmic potential
• The Cahn-Hilliard equation. Recent advances and applications

Cited in

(4)

• Analysis of a mathematical model for brain lactate kinetics
• A singular reaction‐diffusion equation associated with brain lactate kinetics
• Lactate's behavioral switch in the brain: an \textit{in-silico} model
• Optimal control of therapies on a tumor growth model with brain lactate kinetics

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