Optimal control of a model for brain lactate kinetics

DOI10.3233/ASY-221823MaRDI QIDQ6094865FDOQ6094865

Authors: Hussein Raad, Laurence Cherfils, C. Allery, Rémy Guillevin 

Publication date: 14 September 2023

Published in: Asymptotic Analysis (Search for Journal in Brave)

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zbMATH Keywords

Cahn-Hilliard equationoptimal controlwell-posednessnumerical simulationsadjoint equationsFréchet differentiability with respect to the controllactate kinetics

Mathematics Subject Classification ID

Medical applications (general) (92C50) A priori estimates in context of PDEs (35B45) Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Weak solutions to PDEs (35D30) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Analysis of a model for tumor growth and lactate exchanges in a glioma
• Optimal control of treatment time in a diffuse interface model of tumor growth
• The Cahn-Hilliard equation. Recent advances and applications
• Optimal distributed control of an extended model of tumor growth with logarithmic potential
• Numerical optimization. Theoretical and practice aspects
• Analysis of a mathematical model for brain lactate kinetics
• Cahn-Hilliard models for glial cells
• On a tumor growth model with brain lactate kinetics
• Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth
• On an optimal control problem describing lactate production inhibition

Cited In (4)

• Optimal control of therapies on a tumor growth model with brain lactate kinetics
• Lactate's behavioral switch in the brain: an \textit{in-silico} model
• A singular reaction‐diffusion equation associated with brain lactate kinetics
• Analysis of a mathematical model for brain lactate kinetics

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