Optimal distributed control of an extended model of tumor growth with logarithmic potential

DOI10.1007/S00245-018-9538-1MaRDI QIDQ2198160zbMATH OpenOpenAlexWikidataFDO

Authors Andrea Signori

Publication date 9 September 2020

Published in Applied Mathematics and Optimization (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1809.06834

zbMATH Keywords

adjoint systemCahn-Hilliard equationdistributed optimal controlnecessary optimality conditionsoptimal controlphase field modeltumor growth

Mathematics Subject Classification ID

Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Cell biology (92C37) Medical applications (general) (92C50)

Abstract: This paper is intended to tackle the control problem associated with an extended phase field system of Cahn-Hilliard type that is related to a tumor growth model. This system has been investigated in previous contributions from the viewpoint of well-posedness and asymptotic analyses. Here, we aim to extend the mathematical studies around this system by introducing a control variable and handling the corresponding control problem. We try to keep the potential as general as possible, focusing our investigation towards singular potentials, such as the logarithmic one. We establish the existence of optimal control, the Lipschitz continuity of the control-to-state mapping and even its Fr'echet differentiability in suitable Banach spaces. Moreover, we derive the first-order necessary conditions that an optimal control has to satisfy.

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Cited in

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