A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
From MaRDI portal
Publication:4603533
DOI10.1142/S0218202518500148zbMATH Open1380.92029arXiv1701.06656OpenAlexW3104199352MaRDI QIDQ4603533FDOQ4603533
Authors: Harald Garcke, Kei Fong Lam, Robert Nürnberg, Emanuel Sitka 
Publication date: 15 February 2018
Published in: M\(^3\)AS. Mathematical Models \& Methods in Applied Sciences (Search for Journal in Brave)
Abstract: We derive a Cahn-Hilliard-Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a coupling of the Cahn-Hilliard-Darcy equations to a system of reaction-diffusion equations a multitude of phenomena such as nutrient diffusion and consumption, angiogenesis, hypoxia, blood vessel growth, and inhibition by toxic agents, which are released for example by the necrotic cells, can be included. A new feature of the modelling approach is that a volume-averaged velocity is used, which dramatically simplifies the resulting equations. With the help of formally matched asymptotic analysis we develop new sharp interface models. Finite element numerical computations are performed and in particular the effects of necrosis on tumour growth is investigated numerically.
Full work available at URL: https://arxiv.org/abs/1701.06656
Recommendations
- A Cahn-Hilliard-Darcy model for tumour growth with chemotaxis and active transport
- Cahn-Hilliard-Brinkman systems for tumour growth
- On a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials
- Analysis of a Cahn-Hilliard-Brinkman model for tumour growth with chemotaxis
- Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
phase-field modelDarcy flowmatched asymptotic expansionsnecrosisfinite element computationscellular adhesionmultiphase tumour growth
Medical applications (general) (92C50) Reaction-diffusion equations (35K57) Free boundary problems for PDEs (35R35) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60)
Cites Work
- Algorithm 832
- Vector-valued local minimizers of nonconvex variational problems
- Nonlinear simulation of tumor growth
- From 1970 until present: The Keller-Segel model in chemotaxis and its consequences. I
- Generalized Ginzburg-Landau and Cahn-Hilliard equations based on a microforce balance
- Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching
- Thermodynamically consistent, frame indifferent diffuse interface models for incompressible two-phase flows with different densities
- Numerical simulation of a thermodynamically consistent four-species tumor growth model
- Relating phase field and sharp interface approaches to structural topology optimization
- General diffuse-interface theories and an approach to predictive tumor growth modeling
- Initiation of slime mold aggregation viewed as an instability
- A user's guide to PDE models for chemotaxis
- Convergence of the Cahn-Hilliard equation to the Hele-Shaw model
- Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method
- Title not available (Why is that?)
- Model for chemotaxis
- Models of phase segregation and diffusion of atomic species on a lattice
- Design of adaptive finite element software. The finite element toolbox ALBERTA. With CD-ROM
- On anisotropic order parameter models for multi-phase systems and their sharp interface limits
- Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications
- A new ghost cell/level set method for moving boundary problems: application to tumor growth
- Modelling solid tumour growth using the theory of mixtures
- On fully practical finite element approximations of degenerate Cahn-Hilliard systems
- Multispecies model of cell lineages and feedback control in solid tumors
- Nonlinear simulation of the effect of microenvironment on tumor growth
- ON THE CLOSURE OF MASS BALANCE MODELS FOR TUMOR GROWTH
- A MultiPhase Field Concept: Numerical Simulations of Moving Phase Boundaries and Multiple Junctions
- Analysis of a mathematical model of the growth of necrotic tumors
- Second order phase field asymptotics for multi-component systems
- Numerical simulations of immiscible fluid clusters
- A Diffuse Interface Model for Alloys with Multiple Components and Phases
- Three-dimensional multispecies nonlinear tumor growth. II: Tumor invasion and angiogenesis
- Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
- An improved geometry-aware curvature discretization for level set methods: Application to tumor growth
- Diffusional phase transitions in multicomponent systems with a concentration dependent mobility matrix
- Global asymptotic limit of solutions of the Cahn-Hilliard equation
- On a nonequilibrium thermodynamics of capillarity and phase
- Triple-junction motion for an Allen-Cahn/Cahn-Hilliard system
- Tumor growth in complex, evolving microenvironmental geometries: a diffuse domain approach
- Analysis of a diffuse interface model of multispecies tumor growth
- Formal asymptotic limit of a diffuse-interface tumor-growth model
- Global weak solutions and asymptotic limits of a Cahn-Hilliard-Darcy system modelling tumour growth
- A Cahn-Hilliard-Darcy model for tumour growth with chemotaxis and active transport
- A hybrid ten-species phase-field model of tumor growth
- Analysis and numerical solution of stochastic phase‐field models of tumor growth
- Varifold solutions of a sharp interface limit of a diffuse interface model for tumor growth
- Global sharp interface limit of the Hele-Shaw-Cahn-Hilliard system
- A multi-phase Mullins–Sekerka system: matched asymptotic expansions and an implicit time discretisation for the geometric evolution problem
- On a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials
Cited In (69)
- Sharp-interface limit of a multi-phase spectral shape optimization problem for elastic structures
- A nonnegativity preserving scheme for the relaxed Cahn-Hilliard equation with single-well potential and degenerate mobility
- From Vlasov equation to degenerate nonlocal Cahn-Hilliard equation
- On a Phase Field Model for RNA-Protein Dynamics
- Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential
- The subdivision-based IGA-EIEQ numerical scheme for the Cahn-Hilliard-Darcy system of two-phase Hele-Shaw flow on complex curved surfaces
- A structure-preserving, upwind-SAV scheme for the degenerate Cahn-Hilliard equation with applications to simulating surface diffusion
- A fully-decoupled discontinuous Galerkin approximation of the Cahn–Hilliard–Brinkman–Ohta–Kawasaki tumor growth model
- A generalized Allen-Cahn model with mass source and its Cahn-Hilliard limit
- Strong well-posedness and inverse identification problem of a non-local phase field tumour model with degenerate mobilities
- Optimal control of stochastic phase-field models related to tumor growth
- Tumor evolution models of phase-field type with nonlocal effects and angiogenesis
- On a Cahn-Hilliard-Keller-Segel model with generalized logistic source describing tumor growth
- Numerical analysis for a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport
- Analysis of cross-diffusion systems for fluid mixtures driven by a pressure gradient
- On a non-isothermal Cahn-Hilliard model for tumor growth
- Long-time dynamics and optimal control of a diffuse interface model for tumor growth
- Asymptotic analysis of a tumor growth model with fractional operators
- Second‐order, fully decoupled, linearized, and unconditionally stable scalar auxiliary variable schemes for <scp>Cahn–Hilliard–Darcy</scp> system
- Cahn-Hilliard models for glial cells
- Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
- On a Cahn-Hilliard-Brinkman model for tumor growth and its singular limits
- Optimality conditions for an extended tumor growth model with double obstacle potential via deep quench approach
- Optimal medication for tumors modeled by a Cahn-Hilliard-Brinkman equation
- Optimal distributed control of a Cahn-Hilliard-Darcy system with mass sources
- A coupled Cahn-Hilliard model for the proliferative-to-invasive transition of hypoxic glioma cells
- Local and nonlocal phase-field models of tumor growth and invasion due to ECM degradation
- Long time dynamics of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects
- Models of cell motion and tissue growth
- Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
- Bayesian Parameter Identification in Cahn--Hilliard Models for Biological Growth
- Global and exponential attractors for a Cahn-Hilliard equation with logarithmic potentials and mass source
- Existence of weak solutions to a cross-diffusion Cahn-Hilliard type system
- Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme
- Optimal distributed control of an extended model of tumor growth with logarithmic potential
- Nonlocal-to-local convergence of Cahn-Hilliard equations: Neumann boundary conditions and viscosity terms
- Complex far-field geometries determine the stability of solid tumor growth with chemotaxis
- Penalisation of long treatment time and optimal control of a tumour growth model of Cahn-Hilliard type with singular potential
- On a coupled Cahn-Hilliard/Cahn-Hilliard model for the proliferative-to-invasive transition of hypoxic glioma cells
- On the long time behavior of a tumor growth model
- Well-posedness of a diffuse interface model for Hele-Shaw flows
- A second-order decoupled energy stable numerical scheme for Cahn-Hilliard-Hele-Shaw system
- Modeling and simulation of vascular tumors embedded in evolving capillary networks
- Sliding mode control for a phase field system related to tumor growth
- A Cahn-Hilliard-Darcy model for tumour growth with chemotaxis and active transport
- Hessian informed mirror descent
- Nonlocal Cahn-Hilliard-Brinkman system with regular potential: regularity and optimal control
- An efficient stabilized multiple auxiliary variables method for the Cahn-Hilliard-Darcy two-phase flow system
- Existence and weak-strong uniqueness of solutions to the Cahn-Hilliard-Navier-Stokes-Darcy system in superposed free flow and porous media
- Analysis of a tumor model as a multicomponent deformable porous medium
- On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport
- On the Existence of Strong Solutions to the Cahn--Hilliard--Darcy System with Mass Source
- Multiphase modelling of glioma pseudopalisading under acidosis
- Optimal control problems with sparsity for tumor growth models involving variational inequalities
- Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
- Cahn-Hilliard-Brinkman systems for tumour growth
- Optimal control theory and advanced optimality conditions for a diffuse interface model of tumor growth
- On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects
- Analysis of a new multispecies tumor growth model coupling 3D phase-fields with a 1D vascular network
- Parameter identification via optimal control for a Cahn-Hilliard-chemotaxis system with a variable mobility
- A new approach to modelling the formation of necrotic regions in tumours
- The mathematical modeling of cancer growth and angiogenesis by an individual based interacting system
- Finite-element approximation of a phase field model for tumour growth
- A locally modified second-order finite element method for interface problems and its implementation in 2 dimensions
- Unconditional Bound-Preserving and Energy-Dissipating Finite-Volume Schemes for the Cahn-Hilliard Equation
- Efficient numerical simulation of Cahn-Hilliard type models by a dimension splitting method
- An image-informed Cahn-Hilliard Keller-Segel multiphase field model for tumor growth with angiogenesis
- Optimal distributed control of two-dimensional Navier-Stokes-Cahn-Hilliard system with chemotaxis and singular potential
- On a Coupled Cahn–Hilliard System for Copolymer/Homopolymer Mixtures
Uses Software
This page was built for publication: A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q4603533)
