Optimal distributed control of a Cahn-Hilliard-Darcy system with mass sources
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Publication:2019999
DOI10.1007/S00245-019-09555-4zbMATH Open1462.35147arXiv1809.09037OpenAlexW2891690141WikidataQ128589829 ScholiaQ128589829MaRDI QIDQ2019999FDOQ2019999
Authors: Hao Wu, Jürgen Sprekels 
Publication date: 22 April 2021
Published in: Applied Mathematics and Optimization (Search for Journal in Brave)
Abstract: In this paper, we study an optimal control problem for a two-dimensional Cahn-Hilliard-Darcy system with mass sources that arises in the modeling of tumor growth. The aim is to monitor the tumor fraction in a finite time interval in such a way that both the tumor fraction, measured in terms of a tracking type cost functional, is kept under control and minimal harm is inflicted to the patient by administering the control, which could either be a drug or nutrition. We first prove that the optimal control problem admits a solution. Then we show that the control-to-state operator is Fr'echet differentiable between suitable Banach spaces and derive the first-order necessary optimality conditions in terms of the adjoint variables and the usual variational inequality.
Full work available at URL: https://arxiv.org/abs/1809.09037
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