On a diffuse interface model of tumour growth

DOI10.1017/S0956792514000436MaRDI QIDQ4594536zbMATH OpenOpenAlexFDO

Authors Sergio Frigeri, Maurizio Grasselli, Elisabetta Rocca

Publication date 24 November 2017

Published in European Journal of Applied Mathematics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1405.3446

zbMATH Keywords

diffuse interfaceglobal attractorsreaction-diffusion equationsweak solutionswell-posednesstumour growthCahn-Hilliard equations

Mathematics Subject Classification ID

Medical applications (general) (92C50) Reaction-diffusion equations (35K57)

Abstract: We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $varphi$ nonlinearly coupled with a reaction-diffusion equation for $psi$, which represents the nutrient-rich extracellular water volume fraction. The coupling is expressed through a suitable proliferation function $p(varphi)$ multiplied by the differences of the chemical potentials for $varphi$ and $psi$. The system is equipped with no-flux boundary conditions which entails the conservation of the total mass, that is, the spatial average of $varphi+psi$. Here we prove the existence of a weak solution to the associated Cauchy problem, provided that the potential $F$ and $p$ satisfy sufficiently general conditions. Then we show that the weak solution is unique and continuously depends on the initial data, provided that $p$ satisfies slightly stronger growth restrictions. Also, we demonstrate the existence of a strong solution and that any weak solution regularizes in finite time. Finally, we prove the existence of the global attractor in a phase space characterized by an a priori bounded energy.

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