On a diffuse interface model of tumour growth

DOI10.1017/S0956792514000436zbMATH Open1375.92031arXiv1405.3446OpenAlexW2962965237MaRDI QIDQ4594536FDOQ4594536

Authors: Sergio Frigeri, Maurizio Grasselli, Elisabetta Rocca 

Publication date: 24 November 2017

Published in: European Journal of Applied Mathematics (Search for Journal in Brave)

Abstract: We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $varphi$ nonlinearly coupled with a reaction-diffusion equation for $psi$, which represents the nutrient-rich extracellular water volume fraction. The coupling is expressed through a suitable proliferation function $p(varphi)$ multiplied by the differences of the chemical potentials for $varphi$ and $psi$. The system is equipped with no-flux boundary conditions which entails the conservation of the total mass, that is, the spatial average of $varphi+psi$. Here we prove the existence of a weak solution to the associated Cauchy problem, provided that the potential $F$ and $p$ satisfy sufficiently general conditions. Then we show that the weak solution is unique and continuously depends on the initial data, provided that $p$ satisfies slightly stronger growth restrictions. Also, we demonstrate the existence of a strong solution and that any weak solution regularizes in finite time. Finally, we prove the existence of the global attractor in a phase space characterized by an a priori bounded energy.

Full work available at URL: https://arxiv.org/abs/1405.3446

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zbMATH Keywords

diffuse interfaceglobal attractorsreaction-diffusion equationsweak solutionswell-posednesstumour growthCahn-Hilliard equations

Mathematics Subject Classification ID

Medical applications (general) (92C50) Reaction-diffusion equations (35K57)

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