Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme
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Publication:2197190
adjoint systemdistributed optimal controlevolution equationsnecessary optimality conditionsoptimal controlphase field model
Asymptotic behavior of solutions to PDEs (35B40) Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) Unilateral problems for nonlinear parabolic equations and variational inequalities with nonlinear parabolic operators (35K86) PDEs in connection with control and optimization (35Q93) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Medical applications (general) (92C50)
Abstract: We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the tumor cells proliferation in the tissue coupled with a reaction-diffusion equation for the nutrient. This model has already been investigated from the viewpoint of well-posedness, long time behavior, and asymptotic analyses as some parameters go to zero. Starting from these results, we aim to face a related optimal control problem by employing suitable asymptotic schemes. In this direction, further assumptions have to be required. Mainly, we ought to impose some quite general growth conditions for the involved potential and a smallness restriction for a parameter appearing in the system we are going to face. We provide existence of optimal controls and a necessary condition that an optimal control has to satisfy has been characterized as well.
In the paper, the author considers a specific variant of a phase field system. The examined model consists of a Cahn-Hilliard equation governing the evolution of a phase variable, that takes into account the tumor cells proliferation in the tissue, coupled with a reaction-diffusion equation for the nutrient. By the use of an asymptotic scheme, well-posedness and long-time behavior of the model has been investigated. The same scheme is implemented to deduce necessary conditions of optimality for a control problem with a square quality criterion. The solution existence theorem for this problem is proved in the final part of the paper.
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Cited in
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- Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
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