Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme

DOI10.3934/MCRF.2019040zbMATH Open1453.35032arXiv1902.01079OpenAlexW2967494285MaRDI QIDQ2197190FDOQ2197190

Authors: Andrea Signori 

Publication date: 28 August 2020

Published in: Mathematical Control and Related Fields (Search for Journal in Brave)

Abstract: We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the tumor cells proliferation in the tissue coupled with a reaction-diffusion equation for the nutrient. This model has already been investigated from the viewpoint of well-posedness, long time behavior, and asymptotic analyses as some parameters go to zero. Starting from these results, we aim to face a related optimal control problem by employing suitable asymptotic schemes. In this direction, further assumptions have to be required. Mainly, we ought to impose some quite general growth conditions for the involved potential and a smallness restriction for a parameter appearing in the system we are going to face. We provide existence of optimal controls and a necessary condition that an optimal control has to satisfy has been characterized as well.

Full work available at URL: https://arxiv.org/abs/1902.01079

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zbMATH Keywords

evolution equationsoptimal controlnecessary optimality conditionsphase field modeladjoint systemdistributed optimal control

Mathematics Subject Classification ID

Medical applications (general) (92C50) Asymptotic behavior of solutions to PDEs (35B40) Nonlinear initial, boundary and initial-boundary value problems for nonlinear parabolic equations (35K61) Unilateral problems for nonlinear parabolic equations and variational inequalities with nonlinear parabolic operators (35K86) PDEs in connection with control and optimization (35Q93) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20)

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Cited In (20)

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• Strong well-posedness and inverse identification problem of a non-local phase field tumour model with degenerate mobilities
• Optimal control of stochastic phase-field models related to tumor growth
• Optimal distributed control of a Allen-Cahn/Cahn-Hilliard system with temperature
• Asymptotic analysis of a tumor growth model with fractional operators
• Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
• Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
• Optimal distributed control of an extended model of tumor growth with logarithmic potential
• Penalisation of long treatment time and optimal control of a tumour growth model of Cahn-Hilliard type with singular potential
• Parameter identification for nonlocal phase field models for tumor growth via optimal control and asymptotic analysis
• Sliding mode control for a phase field system related to tumor growth
• Optimal distributed control for a coupled phase-field system
• Nutrient control for a viscous Cahn-Hilliard-Keller-Segel model with logistic source describing tumor growth
• Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential
• On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport
• Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
• Optimal control theory and advanced optimality conditions for a diffuse interface model of tumor growth
• Vanishing parameter for an optimal control problem modeling tumor growth
• Sparse Optimal Control of a Phase Field Tumor Model with Mechanical Effects
• Well-posedness and optimal control for a Cahn-Hilliard-Oono system with control in the mass term

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