Asymptotic analysis for Cahn-Hilliard type phase-field systems related to tumor growth in general domains

DOI10.1002/MMA.5520MaRDI QIDQ5380904zbMATHOpenAlexFDO

Authors Shunsuke Kurima

Publication date 6 June 2019

Published in Mathematical Methods in the Applied Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1808.03771

zbMATH Keywords

asymptotic analysistumor growthunbounded domainsCahn-Hilliard systems

Mathematics Subject Classification ID

Quasilinear parabolic equations (35K59) Initial-boundary value problems for higher-order parabolic equations (35K35) Initial-boundary value problems for higher-order parabolic systems (35K52)

Abstract: This article considers a limit system by passing to the limit in the following Cahn--Hilliard type phase field system related to tumor growth as $$: �egin{equation*} �egin{cases} alphapartial_{t} mu_{�eta} + partial_{t} varphi_{�eta}-Deltamu_{�eta} = p(sigma_{�eta} - mu_{�eta}) & mbox{in} Omega imes(0, T), \[1mm] mu_{�eta} = �etapartial_{t} varphi_{�eta} + (-Delta+1)varphi_{�eta} + xi_{�eta} + pi(varphi_{�eta}), xi_{�eta} in B(varphi_{�eta}) & mbox{in} Omega imes(0, T), \[1mm] partial_{t} sigma_{�eta} -Deltasigma_{�eta} = -p(sigma_{�eta} - mu_{�eta}) & mbox{in} Omega imes(0, T) end{cases} end{equation*} in a bounded or an unbounded domain $Omegasubsetmathbb{R}^N$ with smooth bounded boundary. Here $NinmathbbN$, $T>0$, $alpha>0$, $$, $pgeq0$, $B$ is a maximal monotone graph and $pi$ is a Lipschitz continuous function. In the case that $Omega$ is a bounded domain, $p$ and $-Delta+1$ are replaced with $$ and $-Delta$, respectively, and $p$ is a Lipschitz continuous function, Colli--Gilardi--Rocca--Sprekels (2017) have proved existence of solutions to the limit problem with this approach by applying the Aubin--Lions lemma for the compact embedding $H^1(Omega)hookrightarrow{L}^2(Omega)$ and the continuous embedding $L^2(Omega)hookrightarrow(H^1(Omega){)}^{\ast }$. However, the Aubin--Lions lemma cannot be applied directly when $Omega$ is an unbounded domain. The present work establishes existence of weak solutions to the limit problem both in the case of bounded domains and in the case of unbounded domains. To this end we construct an applicable theory for both of these two cases by noting that the embedding $H^1(Omega)hookrightarrow{L}^2(Omega)$ is not compact in the case that $Omega$ is an unbounded domain.

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(6)

• Time discretization of a nonlinear phase field system in general domains
• On a phase field model of Cahn-Hilliard type for tumour growth with mechanical effects
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• Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme

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