On a multi-species Cahn-Hilliard-Darcy tumor growth model with singular potentials

DOI10.4310/CMS.2018.V16.N3.A11MaRDI QIDQ1990552zbMATH OpenOpenAlexFDO

Authors Sergio Frigeri, Kei Fong Lam, Elisabetta Rocca, Giulio Schimperna

Publication date 25 October 2018

Published in Communications in Mathematical Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1709.01469

zbMATH Keywords

Cahn-Hilliard-Darcy systemexistence of weak solutionslogarithmic potentialsnonlinear evolutionary systemtumor growth

Mathematics Subject Classification ID

Weak solutions to PDEs (35D30) Reaction-diffusion equations (35K57) PDEs in connection with fluid mechanics (35Q35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Flows in porous media; filtration; seepage (76S05) General biology and biomathematics (92B05) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: We consider a model describing the evolution of a tumor inside a host tissue in terms of the parameters $varph{i}_p$, $varph{i}_d$ (proliferating and dead cells, respectively), $u$ (cell velocity) and $n$ (nutrient concentration). The variables $varph{i}_p$, $varph{i}_d$ satisfy a Cahn-Hilliard type system with nonzero forcing term (implying that their spatial means are not conserved in time), whereas $u$ obeys a form of the Darcy law and $n$ satisfies a quasistatic diffusion equation. The main novelty of the present work stands in the fact that we are able to consider a configuration potential of singular type implying that the concentration vector $(varph{i}_p,varph{i}_d)$ is constrained to remain in the range of physically admissible values. On the other hand, in view of the presence of nonzero forcing terms, this choice gives rise to a number of mathematical difficulties, especially related to the control of the mean values of $varph{i}_p$ and $varph{i}_d$. For the resulting mathematical problem, by imposing suitable initial-boundary conditions, our main result concerns the existence of weak solutions in a proper regularity class.

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• Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential
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• On a non-local phase-field model for tumour growth with single-well Lennard-Jones potential
• On the hyperbolic relaxation of the chemical potential in a phase field tumor growth model
• Global attractor for a Cahn-Hilliard-chemotaxis model with logistic degradation

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