Analysis of a diffuse interface model of multispecies tumor growth
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Cahn-Hilliard equationDarcy lawdiffuse interface modelreaction-diffusion equationsingular limitstumor growthweak solution
Singular perturbations in context of PDEs (35B25) Weak solutions to PDEs (35D30) Initial-boundary value problems for higher-order parabolic equations (35K35) Reaction-diffusion equations (35K57) PDEs in connection with fluid mechanics (35Q35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Flows in porous media; filtration; seepage (76S05) Biological applications of optics and electromagnetic theory (78A70) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
Abstract: We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods Biomed. Eng., 30 (2014), 726-754]. In this new approach sharp interfaces are replaced by narrow transition layers arising due to adhesive forces among the cell species. Hence, a continuum thermodynamically consistent model is introduced. The resulting PDE system couples four different types of equations: a Cahn-Hilliard type equation for the tumor cells (which include proliferating and dead cells), a Darcy law for the tissue velocity field, whose divergence may be different from 0 and depend on the other variables, a transport equation for the proliferating (viable) tumor cells, and a quasi-static reaction diffusion equation for the nutrient concentration. We establish existence of weak solutions for the PDE system coupled with suitable initial and boundary conditions. In particular, the proliferation function at the boundary is supposed to be nonnegative on the set where the velocity satisfies , where is the outer normal to the boundary of the domain. We also study a singular limit as the diffuse interface coefficient tends to zero.
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