Optimal control of stochastic phase-field models related to tumor growth
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Cahn-Hilliard equationfirst-order necessary conditionsoptimal controlstochastic systems of partial differential equationstumor growth
Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) PDEs with randomness, stochastic partial differential equations (35R60) Existence theories for optimal control problems involving partial differential equations (49J20) Biological applications of optics and electromagnetic theory (78A70)
Abstract: We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.
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Cited in
(24)- Analysis and optimal velocity control of a stochastic convective Cahn-Hilliard equation
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