Asymptotic analysis of a selection model with space
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Publication:890423
DOI10.1016/J.MATPUR.2015.07.006zbMATH Open1327.35011arXiv1407.5870OpenAlexW1578550824WikidataQ60502716 ScholiaQ60502716MaRDI QIDQ890423FDOQ890423
Authors: Sepideh Mirrahimi, Ben{ôı}t Perthame 
Publication date: 10 November 2015
Published in: Journal de Mathématiques Pures et Appliquées. Neuvième Série (Search for Journal in Brave)
Abstract: Selection of a phenotypical trait can be described in mathematical terms by 'stage structured' equations which are usually written under the form of integral equations so as to express competition for resource between individuals whatever is their trait. The solutions exhibit a concentration effect (selection of the fittest); when a small parameter is introduced they converge to a Dirac mass. An additional space variable can be considered in order to take into account local environmental conditions. Here we assume this environment is a single nutrient which diffuses in the domain. In this framework, we prove that the solution converges to a Dirac mass in the physiological trait which depends on time and on the location in space with Lipschitz continuity. The main difficulties come from the lack of compactness in time and trait variables. Strong convergence can be recovered from uniqueness in the limiting constrained equation after Hopf-Cole change of unknown. Our analysis is motivated by a model of tumor growth introduced by Lorz et al. (preprint) in order to explain emergence of resistance to therapy.
Full work available at URL: https://arxiv.org/abs/1407.5870
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Medical applications (general) (92C50) Problems related to evolution (92D15) Singular perturbations in context of PDEs (35B25) Hamilton-Jacobi equations (35F21) Asymptotics of solutions to integral equations (45M05)
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Cited In (26)
- Optimal control of stochastic phase-field models related to tumor growth
- Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments
- Selected topics on reaction-diffusion-advection models from spatial ecology
- Dirac concentrations in a chemostat model of adaptive evolution
- Selection-mutation dynamics with spatial dependence
- Large deviations of a forced velocity-jump process with a Hamilton-Jacobi approach
- Asymptotic analysis of a quantitative genetics model with nonlinear integral operator
- Evolutionary dynamics in vascularised tumours under chemotherapy: mathematical modelling, asymptotic analysis and numerical simulations
- Rare mutations limit of a steady state dispersal evolution model
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- Stability of Dirac concentrations in an integro-PDE model for evolution of dispersal
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- Dynamics of concentration in a population structured by age and a phenotypic trait with mutations. Convergence of the corrector
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- An integro-PDE model for evolution of random dispersal
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- Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy
- Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors
- A Hamilton-Jacobi approach to evolution of dispersal
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