Evolutionary dynamics in vascularised tumours under chemotherapy: mathematical modelling, asymptotic analysis and numerical simulations
evolutionary dynamicsintra-tumour heterogeneitymathematical oncologynon-local partial differential equationsresistance to chemotherapyvascularised tumours
Asymptotic behavior of solutions to PDEs (35B40) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Integro-partial differential equations (35R09) Integro-partial differential equations (45K05) Medical applications (general) (92C50) Population dynamics (general) (92D25)
This work reports a mathematical model, which takes into account spontaneous epimutations introduced as the diffusion term within the equation for phenotypic distribution density and effects of the oxygen concentration and the concentration of the chemotherapeutic agent modelled as a non-local integral reaction term. The dynamics of control substances is described with partial integro-differential equations too. The introduced model is studied analytically as well as numerically, and the illustrated discussion of phenotypic control is provided.
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