Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
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Publication:3383281
Dynamical systems in biology (37N25) Reaction-diffusion equations (35K57) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Sensitivity, stability, well-posedness (49K40) Variational principles of physics (49S05) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
Abstract: This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we discuss the weak well-posedness of the system under very general assumptions for the potentials, which may be singular and nonsmooth. Then, we establish the strong well-posedness of the system in a reduced setting, which however admits the logarithmic potential: this analysis will lay the foundation for the study of the corresponding optimal control problem. Concerning the optimization problem, we address the existence of minimizers and establish both first-order necessary and second-order sufficient conditions for optimality. The mathematically challenging second-order analysis is completely performed here, after showing that the solution mapping is twice continuously differentiable between suitable Banach spaces via the implicit function theorem. Then, we completely identify the second-order Fr'echet derivative of the control-to-state operator and carry out a thorough and detailed investigation about the related properties.
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- Existence of weak solutions to multiphase Cahn-Hilliard-Darcy and Cahn-Hilliard-Brinkman models for stratified tumor growth with chemotaxis and general source terms
- Optimal control of a phase field tumor growth model with chemotaxis and active transport
- Sparse optimal control of a phase field system with singular potentials arising in the modeling of tumor growth
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- Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential
- Optimality conditions for an extended tumor growth model with double obstacle potential via deep quench approach
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