Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
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Publication:3383281
DOI10.1051/COCV/2021072zbMATH Open1473.49053arXiv2009.07574OpenAlexW3176550347MaRDI QIDQ3383281FDOQ3383281
Authors: Pierluigi Colli, Andrea Signori, Jürgen Sprekels 
Publication date: 23 September 2021
Published in: ESAIM: Control, Optimisation and Calculus of Variations (Search for Journal in Brave)
Abstract: This paper concerns a distributed optimal control problem for a tumor growth model of Cahn-Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we discuss the weak well-posedness of the system under very general assumptions for the potentials, which may be singular and nonsmooth. Then, we establish the strong well-posedness of the system in a reduced setting, which however admits the logarithmic potential: this analysis will lay the foundation for the study of the corresponding optimal control problem. Concerning the optimization problem, we address the existence of minimizers and establish both first-order necessary and second-order sufficient conditions for optimality. The mathematically challenging second-order analysis is completely performed here, after showing that the solution mapping is twice continuously differentiable between suitable Banach spaces via the implicit function theorem. Then, we completely identify the second-order Fr'echet derivative of the control-to-state operator and carry out a thorough and detailed investigation about the related properties.
Full work available at URL: https://arxiv.org/abs/2009.07574
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Dynamical systems in biology (37N25) Reaction-diffusion equations (35K57) Existence theories for optimal control problems involving partial differential equations (49J20) Optimality conditions for problems involving partial differential equations (49K20) Sensitivity, stability, well-posedness (49K40) Variational principles of physics (49S05) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
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Cited In (18)
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- Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
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