On a diffuse interface model for tumour growth with non-local interactions and degenerate mobilities

DOI10.1007/978-3-319-64489-9_9zbMATH Open1382.35311arXiv1703.03553OpenAlexW2621583330MaRDI QIDQ1702312FDOQ1702312

Sergio Frigeri, Elisabetta Rocca, Kei Fong Lam

Publication date: 28 February 2018

Abstract: We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a reaction-diffusion equation. For non-degenerate mobilities and smooth potentials, we derive well-posedness results, which are the non-local analogue of those obtained in Frigeri et al. (European J. Appl. Math. 2015). Furthermore, we establish existence of weak solutions for the case of degenerate mobilities and singular potentials, which serves to confine the order parameter to its physically relevant interval. Due to the non-local nature of the equations, under additional assumptions continuous dependence on initial data can also be shown.

Full work available at URL: https://arxiv.org/abs/1703.03553

zbMATH Keywords

weak solutionswell-posednesssingular potentialstumour growthdegenerate mobilitynon-local Cahn-Hilliard equations

Mathematics Subject Classification ID

Weak solutions to PDEs (35D30) Nonlinear parabolic equations (35K55) Reaction-diffusion equations (35K57) Degenerate parabolic equations (35K65) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cited In (31)

• Strong well-posedness and inverse identification problem of a non-local phase field tumour model with degenerate mobilities
• Tumor evolution models of phase-field type with nonlocal effects and angiogenesis
• On a Cahn-Hilliard-Keller-Segel model with generalized logistic source describing tumor growth
• Numerical analysis for a Cahn-Hilliard system modelling tumour growth with chemotaxis and active transport
• Local asymptotics for nonlocal convective Cahn-Hilliard equations with \(W^{1,1}\) kernel and singular potential
• Optimal distributed control for a viscous non-local tumour growth model
• Asymptotic analysis of a tumor growth model with fractional operators
• Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
• Optimality conditions for an extended tumor growth model with double obstacle potential via deep quench approach
• Local and nonlocal phase-field models of tumor growth and invasion due to ECM degradation
• On the unsteady Darcy–Forchheimer–Brinkman equation in local and nonlocal tumor growth models
• Existence of weak solutions to multiphase Cahn–Hilliard–Darcy and Cahn–Hilliard–Brinkman models for stratified tumor growth with chemotaxis and general source terms
• Second-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis
• The stochastic Cahn–Hilliard equation with degenerate mobility and logarithmic potential
• Optimal treatment for a phase field system of Cahn-Hilliard type modeling tumor growth by asymptotic scheme
• Nonlocal-to-local convergence of Cahn-Hilliard equations: Neumann boundary conditions and viscosity terms
• Varifold solutions of a sharp interface limit of a diffuse interface model for tumor growth
• Penalisation of long treatment time and optimal control of a tumour growth model of Cahn-Hilliard type with singular potential
• On the long time behavior of a tumor growth model
• Parameter identification for nonlocal phase field models for tumor growth via optimal control and asymptotic analysis
• Maximal regularity and optimal control for a non-local Cahn-Hilliard tumour growth model
• Well-posedness for a class of phase-field systems modeling prostate cancer growth with fractional operators and general nonlinearities
• Second-Order Sufficient Conditions in the Sparse Optimal Control of a Phase Field Tumor Growth Model with Logarithmic Potential
• Analysis of a tumor model as a multicomponent deformable porous medium
• On a class of non-local phase-field models for tumor growth with possibly singular potentials, chemotaxis, and active transport
• On the Existence of Strong Solutions to the Cahn--Hilliard--Darcy System with Mass Source
• Optimal control problems with sparsity for tumor growth models involving variational inequalities
• Cahn-Hilliard-Brinkman systems for tumour growth
• Evolving interfaces via gradients of geometry-dependent interior Poisson problems: application to tumor growth
• Cahn–Hilliard–Brinkman model for tumor growth with possibly singular potentials
• Regularity of solutions of a fractional porous medium equation

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