On a diffuse interface model for tumour growth with non-local interactions and degenerate mobilities

DOI10.1007/978-3-319-64489-9_9zbMATH1382.35311OpenAlexW2621583330MaRDI QIDQ1702312FDOQ1702312

Authors Sergio Frigeri, Kei Fong Lam, Elisabetta Rocca

Publication date 28 February 2018

Full work available at URL https://arxiv.org/abs/1703.03553

zbMATH Keywords

weak solutionswell-posednesssingular potentialstumour growthdegenerate mobilitynon-local Cahn-Hilliard equations

Mathematics Subject Classification ID

Weak solutions to PDEs (35D30) Nonlinear parabolic equations (35K55) Reaction-diffusion equations (35K57) Degenerate parabolic equations (35K65) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: We study a non-local variant of a diffuse interface model proposed by Hawkins--Darrud et al. (2012) for tumour growth in the presence of a chemical species acting as nutrient. The system consists of a Cahn--Hilliard equation coupled to a reaction-diffusion equation. For non-degenerate mobilities and smooth potentials, we derive well-posedness results, which are the non-local analogue of those obtained in Frigeri et al. (European J. Appl. Math. 2015). Furthermore, we establish existence of weak solutions for the case of degenerate mobilities and singular potentials, which serves to confine the order parameter to its physically relevant interval. Due to the non-local nature of the equations, under additional assumptions continuous dependence on initial data can also be shown.

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