Multiphase modelling of glioma pseudopalisading under acidosis

DOI10.3934/MINE.2022049zbMATH Open1496.35397arXiv2106.15241OpenAlexW3212144989MaRDI QIDQ2167635FDOQ2167635

Anna Zhigun, Pawan Kumar, Christina Surulescu

Publication date: 25 August 2022

Published in: Mathematics in Engineering (Search for Journal in Brave)

Abstract: We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis. The phases considered at the model onset are glioma, normal tissue, necrotic matter, and interstitial fluid in a void-free volume with acidity represented by proton concentration. We start from mass and momentum balance to characterize the respective volume fractions and deduce reaction-cross diffusion equations for the space-time evolution of glioma, normal tissue, and necrosis. These are supplemented with a reaction-diffusion equation for the acidity dynamics and lead to formation of patterns which are typical for high grade gliomas. Unlike previous works, our deduction also works in higher dimensions and involves less restrictions. We also investigate the existence of weak solutions to the obtained system of equations and perform numerical simulations to illustrate the solution behavior and the pattern occurrence.

Full work available at URL: https://arxiv.org/abs/2106.15241

zbMATH Keywords

multiphase modelreaction-cross diffusion equationsglioma pseudopalisade patterns

Mathematics Subject Classification ID

Medical applications (general) (92C50) Weak solutions to PDEs (35D30) Initial-boundary value problems for second-order parabolic equations (35K20) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Physiological flows (76Z05) Developmental biology, pattern formation (92C15)

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Cited In (2)

• Data driven modeling of pseudopalisade pattern formation
• Modelling acidosis and the cell cycle in multicellular tumour spheroids

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