Multiphase modelling of glioma pseudopalisading under acidosis
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Publication:2167635
Medical applications (general) (92C50) Weak solutions to PDEs (35D30) Initial-boundary value problems for second-order parabolic equations (35K20) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Physiological flows (76Z05) Developmental biology, pattern formation (92C15)
Abstract: We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis. The phases considered at the model onset are glioma, normal tissue, necrotic matter, and interstitial fluid in a void-free volume with acidity represented by proton concentration. We start from mass and momentum balance to characterize the respective volume fractions and deduce reaction-cross diffusion equations for the space-time evolution of glioma, normal tissue, and necrosis. These are supplemented with a reaction-diffusion equation for the acidity dynamics and lead to formation of patterns which are typical for high grade gliomas. Unlike previous works, our deduction also works in higher dimensions and involves less restrictions. We also investigate the existence of weak solutions to the obtained system of equations and perform numerical simulations to illustrate the solution behavior and the pattern occurrence.
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Cites work
- A mathematical model of the stress induced during avascular tumour growth
- A mechanical model of tumor encapsulation and transcapsular spread
- A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
- A multiphase model of tumor and tissue growth including cell adhesion and plastic reorganiza\-tion
- A multiscale model for glioma spread including cell-tissue interactions and proliferation
- A multiscale modeling approach to glioma invasion with therapy
- A two-phase model of solid tumour growth
- CONTINUUM THEORIES OF MIXTURES: BASIC THEORY AND HISTORICAL DEVELOPMENT
- Effective equations for anisotropic glioma spread with proliferation: a multiscale approach and comparisons with previous settings
- Entropy structure of a cross-diffusion tumor-growth model
- Glioma follow white matter tracts: a multiscale DTI-based model
- Hypoxic cell waves around necrotic cores in glioblastoma: a biomathematical model and its therapeutic implications
- Mathematical modeling of glioma invasion: acid- and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy
- Mathematical modelling of glioma growth: the use of diffusion tensor imaging (DTI) data to predict the anisotropic pathways of cancer invasion
- Modeling complex living systems. A kinetic theory and stochastic game approach.
- Modeling glioma invasion with anisotropy- and hypoxia-triggered motility enhancement: from subcellular dynamics to macroscopic PDEs with multiple taxis
- Modeling multiple taxis: tumor invasion with phenotypic heterogeneity, haptotaxis, and unilateral interspecies repellence
- Multiphase modeling of tumor growth with matrix remodeling and fibrosis
- Multiphase modelling of cell behaviour on artificial scaffolds: effects of nutrient depletion and spatially nonuniform porosity
- Multiphase modelling of tumour growth and extracellular matrix interaction: mathematical tools and applications
- Multiscale modeling of glioma pseudopalisades: contributions from the tumor microenvironment
- Representation of divergence-free vector fields
- The boundedness-by-entropy method for cross-diffusion systems
- The role of cell-cell interactions in a two-phase model for avascular tumour growth
- Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
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