Uncovering cross-bridge properties that underlie the cardiac active complex modulus using model linearisation techniques

DOI10.1016/J.MBS.2022.108922zbMATH Open1505.92041OpenAlexW4306756780MaRDI QIDQ2103607FDOQ2103607

Authors: Julia H. Musgrave, J. C. Han, Marie-Louise Ward, Andrew J. Taberner, Denis S. Loiselle, Kenneth Tran 

Publication date: 9 December 2022

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2022.108922

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zbMATH Keywords

complex moduluscardiac cross-bridge modelcross-bridge strain dependencecrossbridge work productionsarcomere length dependencesinusoidal analysis

Mathematics Subject Classification ID

Physiology (general) (92C30) Biomechanics (92C10) Physiological flow (92C35)

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• Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin
• In memory of Edmund John Crampin: multi-scale and multi-physics phenomena in biology
• Modelling and disentangling physiological mechanisms: linear and nonlinear identification techniques for analysis of cardiovascular regulation

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