Active force generation in cardiac muscle cells: mathematical modeling and numerical simulation of the actin-myosin interaction
Asymptotic behavior of solutions to PDEs (35B40) Fokker-Planck equations (35Q84) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Numerical solution of discretized equations for initial value and initial-boundary value problems involving PDEs (65M22) Applications to the sciences (65Z05) Experimental work for problems pertaining to biology (92-05) Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)
The authors first review several models describing the interaction between actin and myosin in cardiac muscle cells. The most detailed models are able of capturing phenomena, such as the response to fast steps, occurring at the fastest time scales involved in the force generation mechanism. The issue of parameter identifiability for force generation models is considered. In particular, the authors show, for a modified version of the Huxley model, how the model parameters can be estimated by measurements typically available from experiments.
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