A nonlocal model describing tumor angiogenesis

DOI10.1016/J.NA.2022.113180zbMATH Open1503.35237arXiv2203.07200OpenAlexW4308738113MaRDI QIDQ2105536FDOQ2105536

Authors: Rafael Granero-Belinchón 

Publication date: 8 December 2022

Published in: Nonlinear Analysis. Theory, Methods \& Applications. Series A: Theory and Methods (Search for Journal in Brave)

Abstract: In this paper we study the onset of angiogenesis and derive a new model to describe it. This new model takes the form of a nonlocal Burgers equation with both diffusive and dispersive terms. For a particular value of the parameters, the equation reduces to ${\displaystyle }$ partial_t p-frac{1}{2}(-Delta)^{(alpha-1)/2}H partial_t p=-frac{1}{2}(-Delta)^{alpha/2} p+ ppartial_x p-partial_x p, ${\displaystyle }$ where $H$ denotes the Hilber transform. In addition to the derivation of the new model, we also prove a number of well-posedness results. Finally, some preliminary numerics are shown. These numerics suggest that the dynamics of the equation is rich enough to have solutions that blow up in finite time.

Full work available at URL: https://arxiv.org/abs/2203.07200

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zbMATH Keywords

angiogenesisBurgers equationdispersive equation

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Blow-up in context of PDEs (35B44) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

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Cited In (2)

• Two dimensional soliton in tumor induced angiogenesis
• An angiogenesis model with nonlinear chemotactic response and flux at the tumor boundary

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