A nonlocal model describing tumor angiogenesis

DOI10.1016/J.NA.2022.113180MaRDI QIDQ2105536zbMATH OpenOpenAlexFDO

Authors Rafael Granero-Belinchón

Publication date 8 December 2022

Published in Nonlinear Analysis. Theory, Methods \& Applications. Series A: Theory and Methods (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://arxiv.org/abs/2203.07200

zbMATH Keywords

angiogenesisBurgers equationdispersive equation

Mathematics Subject Classification ID

Existence problems for PDEs: global existence, local existence, non-existence (35A01) Uniqueness problems for PDEs: global uniqueness, local uniqueness, non-uniqueness (35A02) Blow-up in context of PDEs (35B44) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Computational methods for problems pertaining to biology (92-08) Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

Abstract: In this paper we study the onset of angiogenesis and derive a new model to describe it. This new model takes the form of a nonlocal Burgers equation with both diffusive and dispersive terms. For a particular value of the parameters, the equation reduces to ${\displaystyle }$ partial_t p-frac{1}{2}(-Delta)^{(alpha-1)/2}H partial_t p=-frac{1}{2}(-Delta)^{alpha/2} p+ ppartial_x p-partial_x p, ${\displaystyle }$ where $H$ denotes the Hilber transform. In addition to the derivation of the new model, we also prove a number of well-posedness results. Finally, some preliminary numerics are shown. These numerics suggest that the dynamics of the equation is rich enough to have solutions that blow up in finite time.

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Cited in

(2)

• An angiogenesis model with nonlinear chemotactic response and flux at the tumor boundary
• Two dimensional soliton in tumor induced angiogenesis

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