Tumorigenesis and axons regulation for the pancreatic cancer: a mathematical approach

DOI10.1016/J.JTBI.2022.111301zbMATH Open1504.92033arXiv2205.11873OpenAlexW4281555872MaRDI QIDQ2109252FDOQ2109252

Authors: Sophie Chauvet, F. Hubert, Fanny Mann, Mathieu Mezache 

Publication date: 20 December 2022

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: The nervous system is today recognized to play an important role in the development of cancer. Indeed, neurons extend long processes (axons) that grow and infiltrate tumors in order to regulate the progression of the disease in a positive or negative way, depending on the type of neuron considered. Mathematical modelling of this biological process allows to formalize the nerve-tumor interactions and to test hypotheses in silico to better understand this phenomenon. In this work, we introduce a system of differential equations modelling the progression of pancreatic ductal adenocarcinoma (PDAC) coupled with associated changes in axonal innervation. The study of the asymptotic behavior of the model confirms the experimental observations that PDAC development is correlated with the type and densities of axons in the tissue. In addition, we study the identifiability of the model parameters. This informs on the adequacy between the parameters of the model and the experimental data. It leads to significant insights such that the transdifferentiation phenomenon accelerates during the development process of PDAC cells. Finally, we give an example of a simulation of the effects of partial or complete denervation that sheds lights on complex correlation between the cell populations and axons with opposite functions.

Full work available at URL: https://arxiv.org/abs/2205.11873

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zbMATH Keywords

cancersensitivity analysisasymptotic analysisdynamical systemparameters calibration

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Neural biology (92C20) Pathology, pathophysiology (92C32)

Cites Work

• Asymptotic Statistics
• Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
• Convergence results and a Poincaré-Bendixson trichotomy for asymptotically autonomous differential equations
• Evolutionary Games and Population Dynamics
• On Profile Likelihood
• On sensitivity estimation for nonlinear mathematical models
• A mathematical model for pancreatic cancer growth and treatments
• Asymptotically autonomous differential equations in the plane
• Towards a new evolutionary computation. Advances on estimation of distribution algorithms.

Cited In (3)

• The role of exosomes in pancreatic cancer microenvironment
• Modeling the pancreatic cancer microenvironment in search of control targets
• A continuous approach of modeling tumorigenesis and axons regulation for the pancreatic cancer

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