Mathematical modeling of tumor-immune system interactions: the effect of rituximab on breast cancer immune response

DOI10.1016/J.JTBI.2021.111001zbMATH Open1483.92043arXiv2110.01545OpenAlexW3202858699WikidataQ113869617 ScholiaQ113869617MaRDI QIDQ2115998FDOQ2115998

Authors: Vasiliki Bitsouni, Vasilis Tsilidis 

Publication date: 15 March 2022

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8${}^{+}$ T cells, CD4${}^{+}$ T cells and B cells. Furthermore, we use data fitting to prove that the functional response regarding the lysis of breast cancer cells by NK cells has a ratio-dependent form. Additionally, we include in our model the concentration of rituximab - a monoclonal antibody that has been suggested as a potential breast cancer therapy - and test its effect, when the standard, as well as experimental dosages, are administered.

Full work available at URL: https://arxiv.org/abs/2110.01545

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zbMATH Keywords

stability analysisdata fittingratio-dependent functional responseexperimental treatmenttBregs

Mathematics Subject Classification ID

Medical applications (general) (92C50) Nonlinear ordinary differential equations and systems (34A34) Cell biology (92C37) Pathology, pathophysiology (92C32)

Cites Work

• NeuralPDE.jl
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Cited In (7)

• On a moving boundary problem associated with a mathematical model of breast cancer
• Global stability and parameter analysis reinforce therapeutic targets of PD-L1-PD-1 and MDSCs for glioblastoma
• Mathematical modeling of the immune-chemotherapeutic treatment of breast cancer under some control parameters
• Dynamic analysis of a drug resistance evolution model with nonlinear immune response
• B7-H1 and a mathematical model for cytotoxic T cell and tumor cell interaction
• A mathematical study of the role of tbregs in breast cancer
• Mathematical modelling of trastuzumab-induced immune response in an \textit{in vivo} murine model of HER2+ breast cancer

Uses Software

• DifferentialEquations.jl
• NeuralPDE.jl

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